Platelet membrane-based and tumor-associated platelettargeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries. Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines. For example, platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis. In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment. This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation.

Original languageEnglish (US)
Pages (from-to)667-677
Number of pages11
JournalFrontiers of Medicine
Volume12
Issue number6
DOIs
StatePublished - Dec 1 2018

Keywords

  • EPR effect
  • cancer therapy
  • platelet-mimicking delivery systems
  • tumor-associated platelets

ASJC Scopus subject areas

  • Medicine(all)

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