Plasma Perfused over Immobilized Protein A for Breast Cancer

William I. Bensinger, Jean P. Kinet, Georges Hennen, Francis Franckenne, Charly Schaus, Michel Saint-Remy, Pierre Hoyoux, Philippe Mahieu, Thomas M.S. Chang, Thomas V. Holohan, Albert Deisseroth, David S. Terman, James B. Young, William T. Shearer, Carlos Ayus, Daniel E. Lehane, Henry I. Zaleski, Yerach Daskal

Research output: Contribution to journalLetterpeer-review

35 Scopus citations


To the Editor: In the November 12 issue Terman et al. concluded that when plasma from patients with breast cancer was perfused over purified protein A immobilized in a collodion-charcoal matrix and subsequently reinfused, a partial remission was induced in three of five patients.1 We report below our results in the same field. Five patients presenting with breast adenocarcinoma associated with metastatic lesions in bone or liver or both were treated five to 10 times with plasma perfusion over a column of silica covalently linked to 200 mg of purified protein A. Three of the patients were otherwise completely untreated,.

Original languageEnglish (US)
Pages (from-to)935-937
Number of pages3
JournalNew England Journal of Medicine
Issue number15
StatePublished - Apr 15 1982

ASJC Scopus subject areas

  • Medicine(all)


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