Plasma membrane and sarcoplasmic reticulum Ca-ATPase and smooth muscle

Juan M. Gonzalez, Luis J. Jost, Diane Rouse, Wadi N. Suki

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Calcium ions (Ca2+) are involved in the regulation of many cellular activities. The Ca-ATPase(s) of the plasma membrane and of the endoplasmic reticulum play an important role in controlling the intracellular Ca2+ concentration. Therefore, it is not unexpected that these enzymes are modulated by different factors. The activity of the plasma membrane Ca-ATPase is modified by the amount of negatively charged phospholipids surrounding the enzyme. The regulation of the endoplasmic reticulum Ca-ATPase depends on the phosphorylation of phospholamban by cAMP- and cGMP-dependent protein kinase. These two different Ca2+ transport ATPases are present in both visceral and vascular smooth muscle, but tissue- and species-dependent differences in their relative amount have been observed. In this article we will review the characteristics of Ca-ATPases of the smooth muscle.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalMineral and Electrolyte Metabolism
Issue number5-6
StatePublished - Nov 1 1996


  • Ca-ATPase
  • calcium transport
  • plasma membrane
  • sarcoplasmic reticulum
  • vascular smooth muscle

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism


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