Plasma dehydroepiandrosterone sulfate and cardiovascular disease risk in older men and women

Xiaoming Jia, Caroline Sun, Olive Tang, Ivan Gorlov, Vijay Nambi, Salim S. Virani, Dennis T. Villareal, George E. Taffet, Bing Yu, Jan Bressler, Eric Boerwinkle, B. Gwen Windham, James A. De Lemos, Kunihiro Matsushita, Elizabeth Selvin, Erin D. Michos, Ron C. Hoogeveen, Christie M. Ballantyne

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Context: Lower dehydroepiandrosterone-sulfate (DHEA-S) levels have been inconsistently associated with coronary heart disease (CHD) and mortality. Data are limited for heart failure (HF) and association between DHEA-S change and events. Objective: Assess associations between low DHEA-S/DHEA-S change and incident HF hospitalization, CHD, and mortality in older adults. Design: DHEA-S was measured in stored plasma from visits 4 (1996-1998) and 5 (2011-2013) of the Atherosclerosis Risk in Communities study. Follow-up for incident events: 18 years for DHEA-S level; 5.5 years for DHEA-S change. Setting: General community. Participants: Individuals without prevalent cardiovascular disease (n = 8143, mean age 63 years). Main Outcome Measure: Associations between DHEA-S and incident HF hospitalization, CHD, or mortality; associations between 15-year change in DHEA-S (n = 3706) and cardiovascular events. Results: DHEA-S below the 15th sex-specific percentile of the study population (men: 55.4 μg/dL; women: 27.4 μg/dL) was associated with increased HF hospitalization (men: Hazard ratio [HR] 1.30, 95% confidence interval [CI], 1.07-1.58; women: HR 1.42, 95% CI, 1.13-1.79); DHEA-S below the 25th sex-specific percentile (men: 70.0 μg/dL; women: 37.1 μg/dL) was associated with increased death (men: HR 1.12, 95% CI, 1.01-1.25; women: HR 1.19, 95% CI, 1.03-1.37). In men, but not women, greater percentage decrease in DHEA-S was associated with increased HF hospitalization (HR 1.94, 95% CI, 1.11-3.39). Low DHEA-S and change in DHEA-S were not associated with incident CHD. Conclusions: Low DHEA-S is associated with increased risk for HF and mortality but not CHD. Further investigation is warranted to evaluate mechanisms underlying these associations.

Original languageEnglish (US)
Pages (from-to)1-24
Number of pages24
JournalJournal of Clinical Endocrinology and Metabolism
Issue number12
StatePublished - Dec 1 2020


  • Aging
  • DHEA-S
  • Heart failure
  • Mortality

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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