Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity

Paul Scully, Declan P. McKernan, John Keohane, David Groeger, Fergus Shanahan, Timothy G. Dinan, Eamonn Martin Quigley

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


Objectives: Irritable bowel syndrome (IBS) is a functional disorder that is associated with a number of extra-intestinal co-morbidities and a pro-inflammatory profile. This study was designed to examine the cytokine profile among a group of IBS patients with the extra-intestinal co-morbidities fibromyalgia, premenstrual dysmorphic disorder, and chronic fatigue syndrome. Methods: In all, 100 female IBS patients with these co-morbidities, 21 IBS subjects without co-morbidity (pure IBS; Rome II), and 54 age-matched female controls took part in the study. Blood was drawn for measurement of the plasma cytokines interleukin (IL)-1Β, IL-6, IL-8, IL-10, IL-12p70, IL-13, tumor necrosis factor (TNF)α, and interferon γ. The presence of the selected extra-intestinal manifestations was assessed using standard international criteria. Results: Patients with IBS have increased plasma levels of IL-6 and IL-8; those with these extra-intestinal co-morbidities were found to have, in addition, increased levels of IL-1Β and TNFα. No associations were evident between cytokine profiles and the nature of the co-morbidity or number of extra-intestinal co-morbidities present. Conclusions: Although IBS is characterized by a pro-inflammatory profile featuring the pro-inflammatory cytokines IL-6 and IL-8, IBS patients with certain extra-intestinal co-morbid conditions are distinguished by additional elevations in IL-1Β and TNFα.

Original languageEnglish (US)
Pages (from-to)2235-2243
Number of pages9
JournalAmerican Journal of Gastroenterology
Issue number10
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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