Plasma cell dyscrasia with marrow fibrosis. Clinicopathologic syndrome

Louis Vandermolen, Lawrence Rice, Edward C. Lynch

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Five new cases of plasma cell dyscrasia with coexistent myelofibrosis are described and six previously reported cases are reviewed. Four of the new patients and two from the literature had features of a previously unrecognized syndrome. This syndrome was characterized by significant paraprotein levels, marked marrow fibrosis, and plasmacytosis, without features of extramedullary hematopoiesis (agnogenic myeloid metaplasia) and leukoerythroblastosis. These patients were generally severely anemic and commonly leukopenic and thrombocytopenic. In contrast, one of the new patients and four in the literature showed classic features of the myeloproliferative disease, myelofibrosis with agnogenic myeloid metaplasia, along with features of typical multiple myeloma.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalThe American journal of medicine
Volume79
Issue number3
DOIs
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Medicine(all)

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