Plasma 15-F2t-isoprostane in idiopathic pulmonary arterial hypertension

Rui Zhang, Ming Li Sun, You Fei Fan, Xin Jiang, Qin Hua Zhao, Jing He, Lan Wang, P. K. Shailendra, Zeenat Safdar, Zhi Cheng Jing

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background 15-F2t-isoprostane (15-F2t-IsoP), a prostaglandin F2-like compound, is widely recognized as a biomarker of chronic heart failure. This study investigated the potential role and prognostic significance of plasma 15-F2t-IsoP in patients with idiopathic pulmonary arterial hypertension (IPAH). Methods Plasma 15-F 2t-IsoP concentrations were determined in 80 consecutive IPAH patients at the time of their first right heart catheterization, and monitored for 30 ± 12 months. The expression of 15-F2t-IsoP protein in autopsy lung samples was determined by immunohistochemical staining. Results Plasma 15-F2t-IsoP concentrations were significantly increased in patients with IPAH compared with healthy controls (91 pg/ml vs. 30 pg/ml, respectively; P < 0.001). Patients with baseline 15-F2t-IsoP concentrations ≥ 97 pg/ml had a significantly lower survival rate than those with lower baseline concentrations (P < 0.001). During follow-up, 15-F 2t-IsoP concentrations in survivors decreased, whereas concentrations in non-surviving patients increased further (P < 0.05). Elevated concentrations of 15-F2t-IsoP were correlated with a severity of WHO functional class, lower 6-minute walking distance and mixed venous oxygen saturation, higher mean right atrial pressure and brain natriuretic peptide. Multivariate analysis revealed that the plasma 15-F2t-IsoP concentration was an independent factor associated with mortality. Histological studies showed that the expression of 15-F2t-IsoP was up-regulated in remodeled pulmonary vessels. Conclusions An elevated plasma 15-F 2t-IsoP concentration and a further increase during follow-up may be a risk factor for higher mortality in patients with IPAH.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalInternational Journal of Cardiology
Volume175
Issue number2
DOIs
StatePublished - Aug 1 2014

Keywords

  • Biomarkers
  • Idiopathic pulmonary arterial hypertension
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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