Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

Anand A. Joshi; Soniya S. Vaidya; Marie V. St-Pierre; Andrei M. Mikheev; Kelly E. Desino; Abner N. Nyandege; Kenneth L. Audus; Jashvant D. Unadkat; Phillip M. Gerk

doi:10.1007/s11095-016-2028-8

Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

Anand A. Joshi, Soniya S. Vaidya, Marie V. St-Pierre, Andrei M. Mikheev, Kelly E. Desino, Abner N. Nyandege, Kenneth L. Audus, Jashvant D. Unadkat, Phillip M. Gerk

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.

Original language	English (US)
Pages (from-to)	2847-2878
Number of pages	32
Journal	Pharmaceutical Research
Volume	33
Issue number	12
DOIs	https://doi.org/10.1007/s11095-016-2028-8
State	Published - Dec 1 2016

Keywords

P-glycoprotein
breast cancer resistance protein
drug transport
multidrug resistance-associated protein
placenta
regulation of expression

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

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10.1007/s11095-016-2028-8

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title = "Placental ABC Transporters: Biological Impact and Pharmaceutical Significance",

abstract = "The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.",

keywords = "P-glycoprotein, breast cancer resistance protein, drug transport, multidrug resistance-associated protein, placenta, regulation of expression",

author = "Joshi, {Anand A.} and Vaidya, {Soniya S.} and St-Pierre, {Marie V.} and Mikheev, {Andrei M.} and Desino, {Kelly E.} and Nyandege, {Abner N.} and Audus, {Kenneth L.} and Unadkat, {Jashvant D.} and Gerk, {Phillip M.}",

note = "Funding Information: The authors gratefully acknowledge the following sources of support: The Thomas F. and Kate Miller Jeffress Memorial Trust, the VCU School of Pharmacy, the National Institutes of Health (MD002254), VCU Presidential Research Incentive Program and grant P01DA032507 from the National Institute on Drug Abuse. Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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doi = "10.1007/s11095-016-2028-8",

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AU - Joshi, Anand A.

AU - Vaidya, Soniya S.

AU - St-Pierre, Marie V.

AU - Mikheev, Andrei M.

AU - Desino, Kelly E.

AU - Nyandege, Abner N.

AU - Audus, Kenneth L.

AU - Unadkat, Jashvant D.

AU - Gerk, Phillip M.

N1 - Funding Information: The authors gratefully acknowledge the following sources of support: The Thomas F. and Kate Miller Jeffress Memorial Trust, the VCU School of Pharmacy, the National Institutes of Health (MD002254), VCU Presidential Research Incentive Program and grant P01DA032507 from the National Institute on Drug Abuse. Publisher Copyright: © 2016, Springer Science+Business Media New York. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.

AB - The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.

KW - P-glycoprotein

KW - breast cancer resistance protein

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KW - multidrug resistance-associated protein

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KW - regulation of expression

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Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

Abstract

Keywords

ASJC Scopus subject areas

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