TY - JOUR
T1 - Placental ABC Transporters
T2 - Biological Impact and Pharmaceutical Significance
AU - Joshi, Anand A.
AU - Vaidya, Soniya S.
AU - St-Pierre, Marie V.
AU - Mikheev, Andrei M.
AU - Desino, Kelly E.
AU - Nyandege, Abner N.
AU - Audus, Kenneth L.
AU - Unadkat, Jashvant D.
AU - Gerk, Phillip M.
N1 - Funding Information:
The authors gratefully acknowledge the following sources of support: The Thomas F. and Kate Miller Jeffress Memorial Trust, the VCU School of Pharmacy, the National Institutes of Health (MD002254), VCU Presidential Research Incentive Program and grant P01DA032507 from the National Institute on Drug Abuse.
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.
AB - The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.
KW - P-glycoprotein
KW - breast cancer resistance protein
KW - drug transport
KW - multidrug resistance-associated protein
KW - placenta
KW - regulation of expression
UR - http://www.scopus.com/inward/record.url?scp=84988378505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84988378505&partnerID=8YFLogxK
U2 - 10.1007/s11095-016-2028-8
DO - 10.1007/s11095-016-2028-8
M3 - Review article
C2 - 27644937
AN - SCOPUS:84988378505
SN - 0724-8741
VL - 33
SP - 2847
EP - 2878
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 12
ER -