Abstract
Neutrophil recruitment is one of the hallmarks of acute inflammation. A potent neutrophil chemotactic and activating factor, interleukin-8 (IL-8), has been demonstrated to be elevated in body fluids in various human diseases and experimental animal models. Recent investigations on animal disease models using blocking antibodies to IL-8 have revealed the essential involvement of IL-8 in acute inflammation. We previously reported that the administration of a neutralizing antibody against IL-8 prevented the neutrophil infiltration and neutrophil-mediated tissue injury in several animal studies. In addition, we have recently demonstrated that anti-IL-8 treatment is also effective in prevention of two models that are very relevant to clinical situations: cerebral reperfusion injury and endotoxemia- induced acute respiratory distress syndrome-like lung injury. These results further support the hypothesis that. IL-8 has a pivotal role and is a novel target for therapeutic intervention in neutrophil-mediated injury.
Original language | English (US) |
---|---|
Pages (from-to) | 581-587 |
Number of pages | 7 |
Journal | Journal of Leukocyte Biology |
Volume | 62 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1997 |
Keywords
- Acute inflammation
- ARDS-like lung injury
- Neutralizing antibody
- Neutrophil
ASJC Scopus subject areas
- Cell Biology