Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury

Tetsuya Matsumoto, Kenji Yokoi, Naofumi Mukaida, Akihisa Harada, Junkoh Yamashita, Yoh Watanabe, Kouji Matsushima

Research output: Contribution to journalReview article

77 Scopus citations

Abstract

Neutrophil recruitment is one of the hallmarks of acute inflammation. A potent neutrophil chemotactic and activating factor, interleukin-8 (IL-8), has been demonstrated to be elevated in body fluids in various human diseases and experimental animal models. Recent investigations on animal disease models using blocking antibodies to IL-8 have revealed the essential involvement of IL-8 in acute inflammation. We previously reported that the administration of a neutralizing antibody against IL-8 prevented the neutrophil infiltration and neutrophil-mediated tissue injury in several animal studies. In addition, we have recently demonstrated that anti-IL-8 treatment is also effective in prevention of two models that are very relevant to clinical situations: cerebral reperfusion injury and endotoxemia- induced acute respiratory distress syndrome-like lung injury. These results further support the hypothesis that. IL-8 has a pivotal role and is a novel target for therapeutic intervention in neutrophil-mediated injury.

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalJournal of Leukocyte Biology
Volume62
Issue number5
DOIs
StatePublished - Nov 1997

Keywords

  • Acute inflammation
  • ARDS-like lung injury
  • Neutralizing antibody
  • Neutrophil

ASJC Scopus subject areas

  • Cell Biology

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