Pitfalls in Interpretation of PET/CT in the Chest

Chad Strange, Girish S. Shroff, Mylene T. Truong, Eric M. Rohren

Research output: Contribution to journalArticlepeer-review


Whole body positron emission tomography (PET)/computed tomography (CT) imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG) is widely used in oncologic imaging. In the chest, common PET/CT applications include the evaluation of solitary pulmonary nodules, cancer staging, assessment of response to therapy, and detection of residual or recurrent disease. Knowledge of the technical artifacts and potential pitfalls that radiologists may encounter in the interpretation of PET/CT in the thorax is important to avoid misinterpretation and optimize patient management. This article will review pitfalls in the interpretation of PET/CT in the chest related to technical factors, physiologic uptake, false positive findings, false negative findings, and iatrogenic conditions.

Original languageEnglish (US)
Pages (from-to)588-598
Number of pages11
JournalSeminars in Ultrasound, CT and MRI
Issue number6
StatePublished - Dec 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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