Pitavastatin suppresses mitogen activated protein kinase-mediated Erg-1 induction in human vascular smooth muscle cells

Brian D. Lamon, Barbara D. Summers, Antonio M. Gotto, David P. Hajjar

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Statins have been demonstrated to elicit a broad range of cellular events resulting in an attenuation of the inflammatory response and enhanced protection to the components of the vessel wall. The present study was designed to examine the effect of pitavastatin on pathways associated with the proinflammatory gene, early growth response (Egr)-1, in human vascular smooth muscle cells. Pretreatment with pitavastatin resulted in a dose-dependent reduction in Egr-1 protein and suppressed Egr-1 mRNA expression in response to phorbol 12-myristate 13-acetate (PMA). A reduction in Egr-1 expression reduced the activation of NGFI-A binding protein (NAB)-2, an Egr-1-dependent gene. Furthermore, these events appeared to be dependent on the ability of pitavastatin to attenuate signaling cascades associated with extracellular regulated kinase (ERK) 1/2, but not p38 and c-Jun N-terminal kinase (JNK).

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalEuropean Journal of Pharmacology
Volume606
Issue number1-3
DOIs
StatePublished - Mar 15 2009

Keywords

  • Early growth response (Egr)-1
  • Mitogen-activated protein kinase (MAPK)
  • Smooth muscle cells
  • Statins

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Pitavastatin suppresses mitogen activated protein kinase-mediated Erg-1 induction in human vascular smooth muscle cells'. Together they form a unique fingerprint.

Cite this