PIRs mediate innate myeloid cell memory to nonself MHC molecules

Research output: Contribution to journalArticle

Hehua Dai, Peixiang Lan, Daqiang Zhao, Khodor Abou-Daya, Wentao Liu, Wenhao Chen, Andrew J. Friday, Amanda L. Williams, Tao Sun, Jianjiao Chen, Wei Chen, Steven Mortin-Toth, Jayne S. Danska, Chris Wiebe, Peter Nickerson, Tengfang Li, Lisa R. Mathews, Hêth R. Turnquist, Matthew L. Nicotra, Sebastien Gingras & 6 others Eiji Takayama, Hiromi Kubagawa, Mark J. Shlomchik, Martin H. Oberbarnscheidt, Xian Chang Li, Fadi G. Lakkis

Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.

Original languageEnglish (US)
Pages (from-to)1122-1127
Number of pages6
JournalScience (New York, N.Y.)
Volume368
Issue number6495
DOIs
StatePublished - Jun 5 2020

PMID: 32381589

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PIRs mediate innate myeloid cell memory to nonself MHC molecules. / Dai, Hehua; Lan, Peixiang; Zhao, Daqiang; Abou-Daya, Khodor; Liu, Wentao; Chen, Wenhao; Friday, Andrew J.; Williams, Amanda L.; Sun, Tao; Chen, Jianjiao; Chen, Wei; Mortin-Toth, Steven; Danska, Jayne S.; Wiebe, Chris; Nickerson, Peter; Li, Tengfang; Mathews, Lisa R.; Turnquist, Hêth R.; Nicotra, Matthew L.; Gingras, Sebastien; Takayama, Eiji; Kubagawa, Hiromi; Shlomchik, Mark J.; Oberbarnscheidt, Martin H.; Li, Xian Chang; Lakkis, Fadi G.

In: Science (New York, N.Y.), Vol. 368, No. 6495, 05.06.2020, p. 1122-1127.

Research output: Contribution to journalArticle

Harvard

Dai, H, Lan, P, Zhao, D, Abou-Daya, K, Liu, W, Chen, W, Friday, AJ, Williams, AL, Sun, T, Chen, J, Chen, W, Mortin-Toth, S, Danska, JS, Wiebe, C, Nickerson, P, Li, T, Mathews, LR, Turnquist, HR, Nicotra, ML, Gingras, S, Takayama, E, Kubagawa, H, Shlomchik, MJ, Oberbarnscheidt, MH, Li, XC & Lakkis, FG 2020, 'PIRs mediate innate myeloid cell memory to nonself MHC molecules' Science (New York, N.Y.), vol. 368, no. 6495, pp. 1122-1127. https://doi.org/10.1126/science.aax4040

APA

Dai, H., Lan, P., Zhao, D., Abou-Daya, K., Liu, W., Chen, W., ... Lakkis, F. G. (2020). PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science (New York, N.Y.), 368(6495), 1122-1127. https://doi.org/10.1126/science.aax4040

Vancouver

Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science (New York, N.Y.). 2020 Jun 5;368(6495):1122-1127. https://doi.org/10.1126/science.aax4040

Author

Dai, Hehua ; Lan, Peixiang ; Zhao, Daqiang ; Abou-Daya, Khodor ; Liu, Wentao ; Chen, Wenhao ; Friday, Andrew J. ; Williams, Amanda L. ; Sun, Tao ; Chen, Jianjiao ; Chen, Wei ; Mortin-Toth, Steven ; Danska, Jayne S. ; Wiebe, Chris ; Nickerson, Peter ; Li, Tengfang ; Mathews, Lisa R. ; Turnquist, Hêth R. ; Nicotra, Matthew L. ; Gingras, Sebastien ; Takayama, Eiji ; Kubagawa, Hiromi ; Shlomchik, Mark J. ; Oberbarnscheidt, Martin H. ; Li, Xian Chang ; Lakkis, Fadi G. / PIRs mediate innate myeloid cell memory to nonself MHC molecules. In: Science (New York, N.Y.). 2020 ; Vol. 368, No. 6495. pp. 1122-1127.

BibTeX

@article{eba7fc0beb8548dca941c768aefd3a29,
title = "PIRs mediate innate myeloid cell memory to nonself MHC molecules",
abstract = "Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.",
author = "Hehua Dai and Peixiang Lan and Daqiang Zhao and Khodor Abou-Daya and Wentao Liu and Wenhao Chen and Friday, {Andrew J.} and Williams, {Amanda L.} and Tao Sun and Jianjiao Chen and Wei Chen and Steven Mortin-Toth and Danska, {Jayne S.} and Chris Wiebe and Peter Nickerson and Tengfang Li and Mathews, {Lisa R.} and Turnquist, {H{\^e}th R.} and Nicotra, {Matthew L.} and Sebastien Gingras and Eiji Takayama and Hiromi Kubagawa and Shlomchik, {Mark J.} and Oberbarnscheidt, {Martin H.} and Li, {Xian Chang} and Lakkis, {Fadi G.}",
year = "2020",
month = "6",
day = "5",
doi = "10.1126/science.aax4040",
language = "English (US)",
volume = "368",
pages = "1122--1127",
journal = "Science (New York, N.Y.)",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6495",

}

RIS

TY - JOUR

T1 - PIRs mediate innate myeloid cell memory to nonself MHC molecules

AU - Dai, Hehua

AU - Lan, Peixiang

AU - Zhao, Daqiang

AU - Abou-Daya, Khodor

AU - Liu, Wentao

AU - Chen, Wenhao

AU - Friday, Andrew J.

AU - Williams, Amanda L.

AU - Sun, Tao

AU - Chen, Jianjiao

AU - Chen, Wei

AU - Mortin-Toth, Steven

AU - Danska, Jayne S.

AU - Wiebe, Chris

AU - Nickerson, Peter

AU - Li, Tengfang

AU - Mathews, Lisa R.

AU - Turnquist, Hêth R.

AU - Nicotra, Matthew L.

AU - Gingras, Sebastien

AU - Takayama, Eiji

AU - Kubagawa, Hiromi

AU - Shlomchik, Mark J.

AU - Oberbarnscheidt, Martin H.

AU - Li, Xian Chang

AU - Lakkis, Fadi G.

PY - 2020/6/5

Y1 - 2020/6/5

N2 - Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.

AB - Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.

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U2 - 10.1126/science.aax4040

DO - 10.1126/science.aax4040

M3 - Article

VL - 368

SP - 1122

EP - 1127

JO - Science (New York, N.Y.)

T2 - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

SN - 0036-8075

IS - 6495

ER -

ID: 64403717