@article{eba7fc0beb8548dca941c768aefd3a29,
title = "PIRs mediate innate myeloid cell memory to nonself MHC molecules",
abstract = "Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.",
author = "Hehua Dai and Peixiang Lan and Daqiang Zhao and Khodor Abou-Daya and Wentao Liu and Wenhao Chen and Friday, {Andrew J.} and Williams, {Amanda L.} and Tao Sun and Jianjiao Chen and Wei Chen and Steven Mortin-Toth and Danska, {Jayne S.} and Chris Wiebe and Peter Nickerson and Tengfang Li and Mathews, {Lisa R.} and Turnquist, {H{\^e}th R.} and Nicotra, {Matthew L.} and Sebastien Gingras and Eiji Takayama and Hiromi Kubagawa and Shlomchik, {Mark J.} and Oberbarnscheidt, {Martin H.} and Li, {Xian C.} and Lakkis, {Fadi G.}",
note = "Funding Information: We would like to thank C. Bi and Z. Kou of the Transgenic and Gene Targeting Core (Department of Immunology, University of Pittsburgh School of Medicine) for microinjection of zygotes and production of Pira- and Pirb-mutant mice. Funding: This work was supported by NIH grants AI145881 (M.H.O.), AI080779 (X.C.L.), and AI099465 (F.G.L.) and by funds from the Frank and Athena Sarris Chair in Transplantation Biology at the University of Pittsburgh (F.G.L.). J.S.D. was supported by the JDRF, the Canadian Institutes of Health Research, and the SickKids Foundation. Publisher Copyright: {\textcopyright} 2020 American Association for the Advancement of Science. All rights reserved.",
year = "2020",
month = jun,
day = "5",
doi = "10.1126/science.aax4040",
language = "English (US)",
volume = "368",
pages = "1122--1127",
journal = "Science (New York, N.Y.)",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6495",
}