Piribedil Test in Migraine: Neruoendocrinological Aspects

G. Bussone; E. Lamperti; L. LaMantia; A. Vescovi; C. Peccarisi; A. Boiardi

doi:10.1111/j.1526-4610.1986.hed2609482.x

Piribedil Test in Migraine: Neruoendocrinological Aspects

G. Bussone, E. Lamperti, L. LaMantia, A. Vescovi, C. Peccarisi, A. Boiardi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

SYNOPSIS Piribedil is a direct central dopamine receptor agonist drug, clinically useful in the diagnosis of migraine. It mayalso be used in the study of migraine pathogenesis, through evaluating dopaminergic “tone”.The observed effects of Piribedil on GH and PRL release, in this study, indicate the existence of dopaminereceptor hypersensitivity in migraine patients. Furthermore our data suggest also the involvement ofnoradrenergic systems in migraine pathogenesis. Estrogen levels do not influence these neuroendocrinologicalresponses to Piribedil, even though the Piribedil test in these female migraine patients was clinically positive (andtherefore diagnostically useful) only during the perimenstrual phase.

Original language	English (US)
Pages (from-to)	482-485
Number of pages	4
Journal	Headache: The Journal of Head and Face Pain
Volume	26
Issue number	9
DOIs	https://doi.org/10.1111/j.1526-4610.1986.hed2609482.x
State	Published - Oct 1986

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Piribedil Test in Migraine: Neruoendocrinological Aspects",

abstract = "SYNOPSIS Piribedil is a direct central dopamine receptor agonist drug, clinically useful in the diagnosis of migraine. It mayalso be used in the study of migraine pathogenesis, through evaluating dopaminergic “tone”.The observed effects of Piribedil on GH and PRL release, in this study, indicate the existence of dopaminereceptor hypersensitivity in migraine patients. Furthermore our data suggest also the involvement ofnoradrenergic systems in migraine pathogenesis. Estrogen levels do not influence these neuroendocrinologicalresponses to Piribedil, even though the Piribedil test in these female migraine patients was clinically positive (andtherefore diagnostically useful) only during the perimenstrual phase.",

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T1 - Piribedil Test in Migraine

T2 - Neruoendocrinological Aspects

AU - Bussone, G.

AU - Lamperti, E.

AU - LaMantia, L.

AU - Vescovi, A.

AU - Peccarisi, C.

AU - Boiardi, A.

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AB - SYNOPSIS Piribedil is a direct central dopamine receptor agonist drug, clinically useful in the diagnosis of migraine. It mayalso be used in the study of migraine pathogenesis, through evaluating dopaminergic “tone”.The observed effects of Piribedil on GH and PRL release, in this study, indicate the existence of dopaminereceptor hypersensitivity in migraine patients. Furthermore our data suggest also the involvement ofnoradrenergic systems in migraine pathogenesis. Estrogen levels do not influence these neuroendocrinologicalresponses to Piribedil, even though the Piribedil test in these female migraine patients was clinically positive (andtherefore diagnostically useful) only during the perimenstrual phase.

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Piribedil Test in Migraine: Neruoendocrinological Aspects

Abstract

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