Piribedil Test in Migraine: Neruoendocrinological Aspects

G. Bussone, E. Lamperti, L. LaMantia, A. Vescovi, C. Peccarisi, A. Boiardi

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

SYNOPSIS Piribedil is a direct central dopamine receptor agonist drug, clinically useful in the diagnosis of migraine. It mayalso be used in the study of migraine pathogenesis, through evaluating dopaminergic “tone”.The observed effects of Piribedil on GH and PRL release, in this study, indicate the existence of dopaminereceptor hypersensitivity in migraine patients. Furthermore our data suggest also the involvement ofnoradrenergic systems in migraine pathogenesis. Estrogen levels do not influence these neuroendocrinologicalresponses to Piribedil, even though the Piribedil test in these female migraine patients was clinically positive (andtherefore diagnostically useful) only during the perimenstrual phase.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalHeadache: The Journal of Head and Face Pain
Volume26
Issue number9
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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