SYNOPSIS Piribedil is a direct central dopamine receptor agonist drug, clinically useful in the diagnosis of migraine. It mayalso be used in the study of migraine pathogenesis, through evaluating dopaminergic “tone”.The observed effects of Piribedil on GH and PRL release, in this study, indicate the existence of dopaminereceptor hypersensitivity in migraine patients. Furthermore our data suggest also the involvement ofnoradrenergic systems in migraine pathogenesis. Estrogen levels do not influence these neuroendocrinologicalresponses to Piribedil, even though the Piribedil test in these female migraine patients was clinically positive (andtherefore diagnostically useful) only during the perimenstrual phase.
|Original language||English (US)|
|Number of pages||4|
|Journal||Headache: The Journal of Head and Face Pain|
|State||Published - Oct 1986|
ASJC Scopus subject areas
- Clinical Neurology