TY - JOUR
T1 - Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease
AU - Wang, Che
AU - Cai, Zhengxu
AU - Wang, Wei
AU - Wei, Min
AU - Kou, Daqing
AU - Li, Tianbai
AU - Yang, Zhaofei
AU - Guo, Huishu
AU - Le, Weidong
AU - Li, Song
N1 - Funding Information:
This work was supported by funding from Liaoning Science and Technology Project ( 20180550306 and 201683653 ), Innovative Talent supporting Program of Liaoning Province , Youth Elite Project of First Affiliated Hospital Dalian Medical University ( 2017YC005 ), National Key Research and Development Program of China ( 2016YFC1306603 ) and National Natural Sciences Foundation of China (NSFC 81430021 , 81673727 and 81771521 ).
Publisher Copyright:
© 2019 Elsevier Inc.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - Piperine, the major alkaloid constituent of black pepper, has been reported to possess a wide range of pharmacological effects on the central nervous system, including antidepressant, anticonvulsant and anti-ischemic activities. In the present study, we aimed to investigate the therapeutic potential and neuroprotective mechanisms of piperine in an experimental mouse model of sporadic Alzheimer's disease (sAD) induced by intracerebroventricular (ICV) infusion of streptozotocin (STZ). STZ was infused bilaterally at a dose of 1.5 mg/kg/day on day 1 and day 3. From day 8, piperine (2.5–10 mg/kg body weight) was administered intraperitoneally once daily for 15 consecutive days. The locomotor activity and cognitive performance of mice were evaluated using open field test and Morris water maze test, respectively. On day 23, all animals were sacrificed, and the hippocampus was used for biochemical, neurochemical and neuroinflammatory determinations. Our data revealed that the ICV-STZ-infused sAD mouse showed an increased oxidative–nitrosative stress, an altered neurotransmission and an elevated neuroinflammation in hippocampus, as well as significant cognitive deficits. All these alterations can be ameliorated by piperine in a dose-dependent manner. In summary, our findings predict a therapeutic potential of piperine against cognitive deficits in sAD mouse. This effect might be due to its abilities to ameliorate oxidative–nitrosative stress, restore neurotransmission and reduce neuroinflammation.
AB - Piperine, the major alkaloid constituent of black pepper, has been reported to possess a wide range of pharmacological effects on the central nervous system, including antidepressant, anticonvulsant and anti-ischemic activities. In the present study, we aimed to investigate the therapeutic potential and neuroprotective mechanisms of piperine in an experimental mouse model of sporadic Alzheimer's disease (sAD) induced by intracerebroventricular (ICV) infusion of streptozotocin (STZ). STZ was infused bilaterally at a dose of 1.5 mg/kg/day on day 1 and day 3. From day 8, piperine (2.5–10 mg/kg body weight) was administered intraperitoneally once daily for 15 consecutive days. The locomotor activity and cognitive performance of mice were evaluated using open field test and Morris water maze test, respectively. On day 23, all animals were sacrificed, and the hippocampus was used for biochemical, neurochemical and neuroinflammatory determinations. Our data revealed that the ICV-STZ-infused sAD mouse showed an increased oxidative–nitrosative stress, an altered neurotransmission and an elevated neuroinflammation in hippocampus, as well as significant cognitive deficits. All these alterations can be ameliorated by piperine in a dose-dependent manner. In summary, our findings predict a therapeutic potential of piperine against cognitive deficits in sAD mouse. This effect might be due to its abilities to ameliorate oxidative–nitrosative stress, restore neurotransmission and reduce neuroinflammation.
KW - Cognition
KW - Neuroinflammation
KW - Neurotransmission
KW - Oxidative stress
KW - Piperine
KW - Sporadic Alzheimer's disease
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U2 - 10.1016/j.jnutbio.2019.05.009
DO - 10.1016/j.jnutbio.2019.05.009
M3 - Article
C2 - 31207354
AN - SCOPUS:85067255163
VL - 70
SP - 147
EP - 155
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
ER -