Physiological impact of continuous flow on end-organ function: clinical implications in the current era of left ventricular assist devices

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The clinical era of continuous-flow left ventricular assist devices has debunked many myths about the dire need of a pulse for human existence. While this therapy has been documented to provide a clear survival benefit in end-stage heart failure patients, we are now faced with certain morbidity challenges that as of yet have no easy mechanistic physiological explanation. The effect of physiological changes on end-organ function in patients supported by continuous-flow ventricular assist devices may offer insight into some of these morbidities. We therefore present a review of current evidence documenting the impact of continuous flow on end-organ function.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • CF
  • LVAD
  • continuous flow
  • continuous-flow physiology
  • end-organ function
  • left ventricular assist device

ASJC Scopus subject areas

  • Medicine(all)

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