Physicochemical properties affect the synthesis, controlled delivery, degradation and pharmacokinetics of inorganic nanoporous materials

Iman K. Yazdi, Arturas Ziemys, Michael Evangelopoulos, Jonathan O. Martinez, Milos Kojic, Ennio Tasciotti

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Controlling size, shape and uniformity of porous constructs remains a major focus of the development of porous materials. Over the past two decades, we have seen significant developments in the fabrication of new, porous-ordered structures using a wide range of materials, resulting in properties well beyond their traditional use. Porous materials have been considered appealing, due to attractive properties such as pore size length, morphology and surface chemistry. Furthermore, their utilization within the life sciences and medicine has resulted in significant developments in pharmaceutics and medical diagnosis. This article focuses on various classes of porous materials, providing an overview of principle concepts with regard to design and fabrication, surface chemistry and loading and release kinetics. Furthermore, predictions from a multiscale mathematical model revealed the role pore length and diameter could have on payload release kinetics.

Original languageEnglish (US)
Pages (from-to)3057-3075
Number of pages19
JournalNanomedicine
Volume10
Issue number19
DOIs
StatePublished - Oct 1 2015

Keywords

  • controlled release
  • drug delivery
  • nanomaterials
  • nanotechnology
  • pore length
  • pore size
  • porous materials
  • surface chemistry

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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