Physicochemical characterization of self-assembled poly(€-caprolactone) grafted dextran nanoparticles

Madhab Prasad Bajgai; Santosh Aryal; Douk Rae Lee; Soo Jin Park; Hak Yong Kim

doi:10.1007/s00396-007-1795-5

Physicochemical characterization of self-assembled poly(€-caprolactone) grafted dextran nanoparticles

Madhab Prasad Bajgai, Santosh Aryal, Douk Rae Lee, Soo Jin Park, Hak Yong Kim

Houston Methodist

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Amphiphilic graft copolymer composed of poly(€-caprolactone) and dextran was synthesized by ring opening polymerization of €-caprolactone initiated through the hydroxyl end of dextran in the presence of stannous 2-ethylhexanoate [Sn (oct)₂] as a catalyst. It has been widely characterized by Fourier transform infrared spectroscopy, ¹H NMR, and thermogravimetric analysis. Nanoparticles were prepared in aqueous medium by co-solvent evaporation technique at room temperature (25 °C). Hydrodynamic diameter and particle size were measured by dynamic light scattering spectroscopy and atomic force microscopy, respectively. Core-shell geometry of polymeric nanoparticle was characterized by fluorescence spectrophotometer using pyrene as a probe. Critical micelle concentration of polymer in triple distilled water decreased from 6.9 × 10^-4 to 8.9 × 10^-4 g/l with increasing hydrophobic moiety. Further, the physiological stability of the nanoparticles in phosphate buffer saline of pH 7.4 at 37 °C was evaluated, which showed promising in drug delivery system.

Original language	English (US)
Pages (from-to)	517-524
Number of pages	8
Journal	Colloid and Polymer Science
Volume	286
Issue number	5
DOIs	https://doi.org/10.1007/s00396-007-1795-5
State	Published - May 2008

Keywords

Dextran
Graft polymer
Micelles
Nanoparticles
Self-assembled

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Polymers and Plastics
Materials Chemistry
Colloid and Surface Chemistry

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10.1007/s00396-007-1795-5

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title = "Physicochemical characterization of self-assembled poly(€-caprolactone) grafted dextran nanoparticles",

abstract = "Amphiphilic graft copolymer composed of poly(€-caprolactone) and dextran was synthesized by ring opening polymerization of €-caprolactone initiated through the hydroxyl end of dextran in the presence of stannous 2-ethylhexanoate [Sn (oct)2] as a catalyst. It has been widely characterized by Fourier transform infrared spectroscopy, 1H NMR, and thermogravimetric analysis. Nanoparticles were prepared in aqueous medium by co-solvent evaporation technique at room temperature (25 °C). Hydrodynamic diameter and particle size were measured by dynamic light scattering spectroscopy and atomic force microscopy, respectively. Core-shell geometry of polymeric nanoparticle was characterized by fluorescence spectrophotometer using pyrene as a probe. Critical micelle concentration of polymer in triple distilled water decreased from 6.9 × 10-4 to 8.9 × 10-4 g/l with increasing hydrophobic moiety. Further, the physiological stability of the nanoparticles in phosphate buffer saline of pH 7.4 at 37 °C was evaluated, which showed promising in drug delivery system.",

keywords = "Dextran, Graft polymer, Micelles, Nanoparticles, Self-assembled",

author = "Bajgai, {Madhab Prasad} and Santosh Aryal and Lee, {Douk Rae} and Park, {Soo Jin} and Kim, {Hak Yong}",

note = "Funding Information: This research was supported by the Korean Research Foundation (KRF2007-211-D00032), grant funded by the Korean Government (MOEHRD), Korean Government project no. 10028211 through the Ministry of Commerce, Industry and Energy Department and Regional Research Centers Program of the Korean Ministry of Educational and Human Resources Development through the Center for Healthcare Technology Development, Chonbuk National University, Jeonju 562-756, Republic of Korea.",

year = "2008",

month = may,

doi = "10.1007/s00396-007-1795-5",

language = "English (US)",

volume = "286",

pages = "517--524",

journal = "Colloid and Polymer Science",

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AU - Bajgai, Madhab Prasad

AU - Aryal, Santosh

AU - Lee, Douk Rae

AU - Park, Soo Jin

AU - Kim, Hak Yong

N1 - Funding Information: This research was supported by the Korean Research Foundation (KRF2007-211-D00032), grant funded by the Korean Government (MOEHRD), Korean Government project no. 10028211 through the Ministry of Commerce, Industry and Energy Department and Regional Research Centers Program of the Korean Ministry of Educational and Human Resources Development through the Center for Healthcare Technology Development, Chonbuk National University, Jeonju 562-756, Republic of Korea.

PY - 2008/5

Y1 - 2008/5

N2 - Amphiphilic graft copolymer composed of poly(€-caprolactone) and dextran was synthesized by ring opening polymerization of €-caprolactone initiated through the hydroxyl end of dextran in the presence of stannous 2-ethylhexanoate [Sn (oct)2] as a catalyst. It has been widely characterized by Fourier transform infrared spectroscopy, 1H NMR, and thermogravimetric analysis. Nanoparticles were prepared in aqueous medium by co-solvent evaporation technique at room temperature (25 °C). Hydrodynamic diameter and particle size were measured by dynamic light scattering spectroscopy and atomic force microscopy, respectively. Core-shell geometry of polymeric nanoparticle was characterized by fluorescence spectrophotometer using pyrene as a probe. Critical micelle concentration of polymer in triple distilled water decreased from 6.9 × 10-4 to 8.9 × 10-4 g/l with increasing hydrophobic moiety. Further, the physiological stability of the nanoparticles in phosphate buffer saline of pH 7.4 at 37 °C was evaluated, which showed promising in drug delivery system.

AB - Amphiphilic graft copolymer composed of poly(€-caprolactone) and dextran was synthesized by ring opening polymerization of €-caprolactone initiated through the hydroxyl end of dextran in the presence of stannous 2-ethylhexanoate [Sn (oct)2] as a catalyst. It has been widely characterized by Fourier transform infrared spectroscopy, 1H NMR, and thermogravimetric analysis. Nanoparticles were prepared in aqueous medium by co-solvent evaporation technique at room temperature (25 °C). Hydrodynamic diameter and particle size were measured by dynamic light scattering spectroscopy and atomic force microscopy, respectively. Core-shell geometry of polymeric nanoparticle was characterized by fluorescence spectrophotometer using pyrene as a probe. Critical micelle concentration of polymer in triple distilled water decreased from 6.9 × 10-4 to 8.9 × 10-4 g/l with increasing hydrophobic moiety. Further, the physiological stability of the nanoparticles in phosphate buffer saline of pH 7.4 at 37 °C was evaluated, which showed promising in drug delivery system.

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KW - Self-assembled

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Physicochemical characterization of self-assembled poly(€-caprolactone) grafted dextran nanoparticles

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