Physicochemical characterization of self-assembled poly(€-caprolactone) grafted dextran nanoparticles

Madhab Prasad Bajgai, Santosh Aryal, Douk Rae Lee, Soo Jin Park, Hak Yong Kim

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Amphiphilic graft copolymer composed of poly(€-caprolactone) and dextran was synthesized by ring opening polymerization of €-caprolactone initiated through the hydroxyl end of dextran in the presence of stannous 2-ethylhexanoate [Sn (oct)2] as a catalyst. It has been widely characterized by Fourier transform infrared spectroscopy, 1H NMR, and thermogravimetric analysis. Nanoparticles were prepared in aqueous medium by co-solvent evaporation technique at room temperature (25 °C). Hydrodynamic diameter and particle size were measured by dynamic light scattering spectroscopy and atomic force microscopy, respectively. Core-shell geometry of polymeric nanoparticle was characterized by fluorescence spectrophotometer using pyrene as a probe. Critical micelle concentration of polymer in triple distilled water decreased from 6.9 × 10-4 to 8.9 × 10-4 g/l with increasing hydrophobic moiety. Further, the physiological stability of the nanoparticles in phosphate buffer saline of pH 7.4 at 37 °C was evaluated, which showed promising in drug delivery system.

Original languageEnglish (US)
Pages (from-to)517-524
Number of pages8
JournalColloid and Polymer Science
Volume286
Issue number5
DOIs
StatePublished - May 1 2008

Keywords

  • Dextran
  • Graft polymer
  • Micelles
  • Nanoparticles
  • Self-assembled

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Materials Chemistry
  • Colloid and Surface Chemistry

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