Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: The Look AHEAD study

Research output: Contribution to journalArticle

Denise K. Houston, Rebecca H. Neiberg, Michael E. Miller, James O. Hill, John M. Jakicic, Karen C. Johnson, Edward W. Gregg, Van S. Hubbard, Xavier Pi-Sunyer, W. Jack Rejeski, Rena R. Wing, John P. Bantle, Elizabeth Beale, Robert I. Berkowitz, Maria Cassidy-Begay, Jeanne M. Clark, Mace Coday, Linda M. Delahanty, Gareth Dutton, Caitlin Egan & 24 others John P. Foreyt, Frank L. Greenway, Helen P. Hazuda, Andrea Hergenroeder, Edward S. Horton, Robert W. Jeffery, Steven E. Kahn, Anne Kure, William C. Knowler, Cora E. Lewis, Corby K. Martin, Sara Michaels, Maria G. Montez, David M. Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A. Wadden, Karen White, Susan Z. Yanovski, Ping Zhang, Stephen B. Kritchevsky

Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial.

Methods: Overweight and obese (body mass index ≥ 25 kg/m2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783).

Results: Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p = .002, and 0.023 [0.012 to 0.034] m/sec, p < .0001, respectively) and higher SPPBexp scores (0.037 [0.011 to 0.063], p = .005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPBexp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p = .01).

Conclusions: An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes.

ClinicalTrials.gov Identifier: NCT00017953.

Original languageEnglish (US)
Pages (from-to)1552-1559
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume73
Issue number11
Early online dateOct 19 2017
DOIs
StatePublished - Oct 8 2018

PMID: 29053861

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Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes : The Look AHEAD study. / Houston, Denise K.; Neiberg, Rebecca H.; Miller, Michael E.; Hill, James O.; Jakicic, John M.; Johnson, Karen C.; Gregg, Edward W.; Hubbard, Van S.; Pi-Sunyer, Xavier; Rejeski, W. Jack; Wing, Rena R.; Bantle, John P.; Beale, Elizabeth; Berkowitz, Robert I.; Cassidy-Begay, Maria; Clark, Jeanne M.; Coday, Mace; Delahanty, Linda M.; Dutton, Gareth; Egan, Caitlin; Foreyt, John P.; Greenway, Frank L.; Hazuda, Helen P.; Hergenroeder, Andrea; Horton, Edward S.; Jeffery, Robert W.; Kahn, Steven E.; Kure, Anne; Knowler, William C.; Lewis, Cora E.; Martin, Corby K.; Michaels, Sara; Montez, Maria G.; Nathan, David M.; Patricio, Jennifer; Peters, Anne; Pownall, Henry; Regensteiner, Judith; Steinburg, Helmut; Wadden, Thomas A.; White, Karen; Yanovski, Susan Z.; Zhang, Ping; Kritchevsky, Stephen B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 73, No. 11, 08.10.2018, p. 1552-1559.

Research output: Contribution to journalArticle

Harvard

Houston, DK, Neiberg, RH, Miller, ME, Hill, JO, Jakicic, JM, Johnson, KC, Gregg, EW, Hubbard, VS, Pi-Sunyer, X, Rejeski, WJ, Wing, RR, Bantle, JP, Beale, E, Berkowitz, RI, Cassidy-Begay, M, Clark, JM, Coday, M, Delahanty, LM, Dutton, G, Egan, C, Foreyt, JP, Greenway, FL, Hazuda, HP, Hergenroeder, A, Horton, ES, Jeffery, RW, Kahn, SE, Kure, A, Knowler, WC, Lewis, CE, Martin, CK, Michaels, S, Montez, MG, Nathan, DM, Patricio, J, Peters, A, Pownall, H, Regensteiner, J, Steinburg, H, Wadden, TA, White, K, Yanovski, SZ, Zhang, P & Kritchevsky, SB 2018, 'Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: The Look AHEAD study' Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 73, no. 11, pp. 1552-1559. https://doi.org/10.1093/gerona/glx204

APA

Houston, D. K., Neiberg, R. H., Miller, M. E., Hill, J. O., Jakicic, J. M., Johnson, K. C., ... Kritchevsky, S. B. (2018). Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: The Look AHEAD study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73(11), 1552-1559. https://doi.org/10.1093/gerona/glx204

Vancouver

Houston DK, Neiberg RH, Miller ME, Hill JO, Jakicic JM, Johnson KC et al. Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: The Look AHEAD study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2018 Oct 8;73(11):1552-1559. https://doi.org/10.1093/gerona/glx204

Author

Houston, Denise K. ; Neiberg, Rebecca H. ; Miller, Michael E. ; Hill, James O. ; Jakicic, John M. ; Johnson, Karen C. ; Gregg, Edward W. ; Hubbard, Van S. ; Pi-Sunyer, Xavier ; Rejeski, W. Jack ; Wing, Rena R. ; Bantle, John P. ; Beale, Elizabeth ; Berkowitz, Robert I. ; Cassidy-Begay, Maria ; Clark, Jeanne M. ; Coday, Mace ; Delahanty, Linda M. ; Dutton, Gareth ; Egan, Caitlin ; Foreyt, John P. ; Greenway, Frank L. ; Hazuda, Helen P. ; Hergenroeder, Andrea ; Horton, Edward S. ; Jeffery, Robert W. ; Kahn, Steven E. ; Kure, Anne ; Knowler, William C. ; Lewis, Cora E. ; Martin, Corby K. ; Michaels, Sara ; Montez, Maria G. ; Nathan, David M. ; Patricio, Jennifer ; Peters, Anne ; Pownall, Henry ; Regensteiner, Judith ; Steinburg, Helmut ; Wadden, Thomas A. ; White, Karen ; Yanovski, Susan Z. ; Zhang, Ping ; Kritchevsky, Stephen B. / Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes : The Look AHEAD study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2018 ; Vol. 73, No. 11. pp. 1552-1559.

BibTeX

@article{ef2a0d65a4ff4508af0db8dd8c4ab200,
title = "Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: The Look AHEAD study",
abstract = "Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial.Methods: Overweight and obese (body mass index ≥ 25 kg/m2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783).Results: Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95{\%} CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95{\%} CI]: 0.019 [0.007 to 0.031] m/s, p = .002, and 0.023 [0.012 to 0.034] m/sec, p < .0001, respectively) and higher SPPBexp scores (0.037 [0.011 to 0.063], p = .005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPBexp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p = .01).Conclusions: An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes.ClinicalTrials.gov Identifier: NCT00017953.",
keywords = "Diabetes, Mobility, Physical function, Weight loss",
author = "Houston, {Denise K.} and Neiberg, {Rebecca H.} and Miller, {Michael E.} and Hill, {James O.} and Jakicic, {John M.} and Johnson, {Karen C.} and Gregg, {Edward W.} and Hubbard, {Van S.} and Xavier Pi-Sunyer and Rejeski, {W. Jack} and Wing, {Rena R.} and Bantle, {John P.} and Elizabeth Beale and Berkowitz, {Robert I.} and Maria Cassidy-Begay and Clark, {Jeanne M.} and Mace Coday and Delahanty, {Linda M.} and Gareth Dutton and Caitlin Egan and Foreyt, {John P.} and Greenway, {Frank L.} and Hazuda, {Helen P.} and Andrea Hergenroeder and Horton, {Edward S.} and Jeffery, {Robert W.} and Kahn, {Steven E.} and Anne Kure and Knowler, {William C.} and Lewis, {Cora E.} and Martin, {Corby K.} and Sara Michaels and Montez, {Maria G.} and Nathan, {David M.} and Jennifer Patricio and Anne Peters and Henry Pownall and Judith Regensteiner and Helmut Steinburg and Wadden, {Thomas A.} and Karen White and Yanovski, {Susan Z.} and Ping Zhang and Kritchevsky, {Stephen B.}",
year = "2018",
month = "10",
day = "8",
doi = "10.1093/gerona/glx204",
language = "English (US)",
volume = "73",
pages = "1552--1559",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes

T2 - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

AU - Houston, Denise K.

AU - Neiberg, Rebecca H.

AU - Miller, Michael E.

AU - Hill, James O.

AU - Jakicic, John M.

AU - Johnson, Karen C.

AU - Gregg, Edward W.

AU - Hubbard, Van S.

AU - Pi-Sunyer, Xavier

AU - Rejeski, W. Jack

AU - Wing, Rena R.

AU - Bantle, John P.

AU - Beale, Elizabeth

AU - Berkowitz, Robert I.

AU - Cassidy-Begay, Maria

AU - Clark, Jeanne M.

AU - Coday, Mace

AU - Delahanty, Linda M.

AU - Dutton, Gareth

AU - Egan, Caitlin

AU - Foreyt, John P.

AU - Greenway, Frank L.

AU - Hazuda, Helen P.

AU - Hergenroeder, Andrea

AU - Horton, Edward S.

AU - Jeffery, Robert W.

AU - Kahn, Steven E.

AU - Kure, Anne

AU - Knowler, William C.

AU - Lewis, Cora E.

AU - Martin, Corby K.

AU - Michaels, Sara

AU - Montez, Maria G.

AU - Nathan, David M.

AU - Patricio, Jennifer

AU - Peters, Anne

AU - Pownall, Henry

AU - Regensteiner, Judith

AU - Steinburg, Helmut

AU - Wadden, Thomas A.

AU - White, Karen

AU - Yanovski, Susan Z.

AU - Zhang, Ping

AU - Kritchevsky, Stephen B.

PY - 2018/10/8

Y1 - 2018/10/8

N2 - Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial.Methods: Overweight and obese (body mass index ≥ 25 kg/m2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783).Results: Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p = .002, and 0.023 [0.012 to 0.034] m/sec, p < .0001, respectively) and higher SPPBexp scores (0.037 [0.011 to 0.063], p = .005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPBexp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p = .01).Conclusions: An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes.ClinicalTrials.gov Identifier: NCT00017953.

AB - Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial.Methods: Overweight and obese (body mass index ≥ 25 kg/m2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783).Results: Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p = .002, and 0.023 [0.012 to 0.034] m/sec, p < .0001, respectively) and higher SPPBexp scores (0.037 [0.011 to 0.063], p = .005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPBexp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p = .01).Conclusions: An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes.ClinicalTrials.gov Identifier: NCT00017953.

KW - Diabetes

KW - Mobility

KW - Physical function

KW - Weight loss

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UR - http://www.scopus.com/inward/citedby.url?scp=85054777629&partnerID=8YFLogxK

U2 - 10.1093/gerona/glx204

DO - 10.1093/gerona/glx204

M3 - Article

VL - 73

SP - 1552

EP - 1559

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 11

ER -

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