TY - GEN
T1 - Photoacoustic imaging in the evaluation of laser controlled drug release using gold nanostructure agents
AU - Sun, Yao
AU - Li, King C.P.
AU - O'Neill, Brian
PY - 2013
Y1 - 2013
N2 - This paper presents an in vitro study in photoacoustic evaluation of laser controlled drug release by using gold nanostructure agents. Laser controlled drug release has been studied and reported by using high intensity nanosecond laser source and optical absorbing gold nanostructures. With the same nanosecond laser source in low intensity, photoacoustic imaging technique can be employed to evaluate the laser controlled drug release, which makes it promising to combine low energy photoacoustic imaging/evaluation with high energy laser controlled drug delivery in a non-radiation, low cost and minimum modified theranostic platform. As an effort to test the feasibility, gold nanoparticles and gold nanorods which have strong absorption of laser specifically in 531 nm and 808nm to trig the drug release in carriers were evaluated in high energy laser treatment and low energy photoacoustic imaging. 20%-50% drop of the intensity in the photoacoustic images has been observed in gold nanoparticles solutions and gold nanorods solutions, after being treated by high energy laser. This study suggests that it is possible to evaluate the high energy laser controlled drug release with low energy photoacoustic imaging method in a non-complex theranostic platform.
AB - This paper presents an in vitro study in photoacoustic evaluation of laser controlled drug release by using gold nanostructure agents. Laser controlled drug release has been studied and reported by using high intensity nanosecond laser source and optical absorbing gold nanostructures. With the same nanosecond laser source in low intensity, photoacoustic imaging technique can be employed to evaluate the laser controlled drug release, which makes it promising to combine low energy photoacoustic imaging/evaluation with high energy laser controlled drug delivery in a non-radiation, low cost and minimum modified theranostic platform. As an effort to test the feasibility, gold nanoparticles and gold nanorods which have strong absorption of laser specifically in 531 nm and 808nm to trig the drug release in carriers were evaluated in high energy laser treatment and low energy photoacoustic imaging. 20%-50% drop of the intensity in the photoacoustic images has been observed in gold nanoparticles solutions and gold nanorods solutions, after being treated by high energy laser. This study suggests that it is possible to evaluate the high energy laser controlled drug release with low energy photoacoustic imaging method in a non-complex theranostic platform.
KW - laser controlled drug release
KW - photoacoustic imaging
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=84878079278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878079278&partnerID=8YFLogxK
U2 - 10.1117/12.2004662
DO - 10.1117/12.2004662
M3 - Conference contribution
AN - SCOPUS:84878079278
SN - 9780819493507
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
T2 - Photons Plus Ultrasound: Imaging and Sensing 2013
Y2 - 3 February 2013 through 5 February 2013
ER -