Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase

Clifford G. Andrew; Allen D. Roses; Richard R. Almon; Stanley H. Appel

doi:10.1126/science.182.4115.927

Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase

Clifford G. Andrew, Allen D. Roses, Richard R. Almon, Stanley H. Appel

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Abstract

A membrane bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.

Original language	English (US)
Pages (from-to)	927-929
Number of pages	3
Journal	Science
Volume	182
Issue number	4115
DOIs	https://doi.org/10.1126/science.182.4115.927
State	Published - Jan 1 1973

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title = "Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase",

abstract = "A membrane bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.",

author = "Andrew, \{Clifford G.\} and Roses, \{Allen D.\} and Almon, \{Richard R.\} and Appel, \{Stanley H.\}",

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T2 - Identification of a membrane-bound protein kinase

AU - Andrew, Clifford G.

AU - Roses, Allen D.

AU - Almon, Richard R.

AU - Appel, Stanley H.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - A membrane bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.

AB - A membrane bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.

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AN - SCOPUS:0015908712

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Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase

Abstract

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