Phenytoin and Membrane Fluidity in Myotonic Dystrophy

Allen D. Roses, D. Allan Butterfield, Stanley H. Appel, Donald B. Chestnut

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin 'normalizes' fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.

Original languageEnglish (US)
Pages (from-to)535-538
Number of pages4
JournalArchives of neurology
Volume32
Issue number8
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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