Phenotypic expression of the myotonic dystrophy gene in monozygotic twins

J. R. Dubel, R. M. Armstrong, M. B. Perryman, H. F. Epstein, Tetsuo Ashizawa

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Phenotypic expression of the myotonic dystrophy (DM) gene is highly variable even within the same family. To investigate the importance of genetic and nongenetic factors on phenotypic variability, we studied phenotypic expression in two DM twin sets with monozygosity confirmed by DNA polymorphism analysis. Our observations suggest that genetic factors are primarily responsible for modulating pleiotropic expression of the DM gene.

Original languageEnglish (US)
Pages (from-to)1815-1817
Number of pages3
JournalNeurology
Volume42
Issue number9
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Clinical Neurology

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