Phasic regional myocardial inflow and outflow: Comparison of theory and experiments

R. S. Chadwick, A. Tedgui, J. B. Michel, J. Ohayon, B. I. Levy

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We developed a theory for regional blood flow in the beating heart and validated it with measurements of coronary arterial inflow and venous outflow in the open-chest anesthetized dog. The model used measured aortic, left ventricular, and coronary sinus pressures as input data under control conditions and during long diastoles induced by vagal stimulation. A nonlinear two-compartment lumped model for each transmural layer was obtained by spatial averaging a continuum description of the myocardial microcirculation based on morphometric measurements and appropriate fluid and vascular mechanics principles. The chief results and conclusions of the study are 1) an intramyocardial time constant on the order of 1 s is required to explain the phase opposition between inflow and outflow; 2) capillary and venous perfusion are in phase with arterial pressure, and arterial flow is out of phase with arterial pressure except in superficial intramural layers; 3) subendocardial retrograde systolic flow increases with increased contractility and time constants and decreased arterial pressure; and 4) endocardial capillary and venule volume change by 5.5 and 10%, respectively, during the control cardiac cycle.

Original languageEnglish (US)
Pages (from-to)H1687-H1698
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume258
Issue number6 27-6
DOIs
StatePublished - 1990

Keywords

  • canine
  • epicardial vein pulse-wave velocity
  • intramyocardial time constant
  • volume changes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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