@article{b775f764bed2413cb9ff8f324d1bd06f,
title = "Phase I study of H5.020CMV.PDGF-β to treat venous leg ulcer disease",
abstract = "Venous leg ulcers are a prevalent nonhealing wound of the lower extremity. Although topically applied growth factors successfully improve wound repair in animal studies, similar studies on humans with venous leg ulcers have not been successful. This study was designed to evaluate the acute safety and biologic feasibility of peri-ulcer injection of a replication-incompetent adenoviral construct expressing platelet-derived growth factor-β (PDGF-β). In this phase I study, we demonstrate the initial safety, feasibility, and biologic plausibility of using H5.020CMV.PDGF-β to treat venous leg ulcer disease.",
author = "Margolis, {David J.} and Morris, {Lee M.} and Maryte Papadopoulos and Linda Weinberg and Filip, {Jennifer C.} and Lang, {Stephanie A.} and Vaikunth, {Sachin S.} and Crombleholme, {Timothy M.}",
note = "Funding Information: The project described was supported by contract number N01-AR092238 and grant number K24AR002212 from the National Institute of Arthritis, Musculoskeletal and Skin Disease and UL1RR024134 from the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health. We acknowledge Meenhard Herlyn (Wistar Institute, Philadelphia PA) for his guidance, encouragement, and contributions to this study. We also acknowledge and thank the Data Safety Monitoring Board for their service and commitment to this study. The members were Vincent Falanga (Chair), Gail Woodbury, Eric Bernstein, Yuko Palesch and Karl Sylvester. The work was conducted in Philadelphia, Pennsylvania, USA. ",
year = "2009",
doi = "10.1038/mt.2009.169",
language = "English (US)",
volume = "17",
pages = "1822--1829",
journal = "Molecular therapy : the journal of the American Society of Gene Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "10",
}