Abstract

The evaluation and management of gastric motor dysfunction continues to represent a significant clinical challenge. The very definition of what constitutes a clinically relevant disturbance of gastric motility remains unclear. The spectrum of gastroparesis extends from those with classical symptoms and severe delay of gastric emptying to those with dyspepsia and a mild delay in emptying rate. Indeed, for many patients with dyspepsia, the role of gastric emptying delay in the pathogenesis of symptoms, remains ; unclear. Any assessment "of the efficacy of any therapeutic class in gastroparesis must be mindful, therefore, of these variations in definition. For those individuals with severe established gastroparesis, therapeutic success often remains elusive and iv. erythromycin and oral dopamine antagonists, or substituted benzamides, remain the best options for acute severe exacerbations and chronic maintenance therapy, respectively. Alternatives, currently under investigation, include a number of 5-HT4 agonists, macrolides devoid of antibiotic activity, CCK antagonists and gastric electrical stimulation. Other novel approaches include strategies to address some of the regional abnormalities in gastric motor function that have been identified in some patients with dyspepsia. 2000

Original languageEnglish (US)
Pages (from-to)881-887
Number of pages7
JournalExpert Opinion on Pharmacotherapy
Volume1
Issue number5
DOIs
StatePublished - Jan 1 2000

Keywords

  • CCK antagonists
  • Cholingeric agonists
  • Cisapride
  • Domperidone
  • Dopamine antagonists
  • Dyspepsia
  • Erythromycin
  • Gastric dysmotility
  • Gastric emptying
  • Gastric pacing
  • Gastric-motor activity
  • Gastroparssis
  • Loxiglumide
  • Macrolides

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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