Abstract
Age-associated cognitive impairments affect an individual's quality of life and are a growing problem in society. Therefore, therapeutic strategies to treat age-related cognitive decline are needed to enhance the quality of life among the elderly. Activation of the Nr4a family of transcription factors has been closely linked to memory formation and dysregulation of these transcription factors is thought to be associated with age-related cognitive decline. Previously, we have shown that Nr4a transcription can be activated by synthetic bisindole-derived compounds (C-DIM). C-DIM compounds enhance synaptic plasticity and long-term contextual fear memory in young healthy mice. In this study, we show that activation of Nr4a2 by 1,1-bis(3′-Indolyl)-1-(p-chlorophenyl) methane (C-DIM12), enhances long-term spatial memory in young mice and rescues memory deficits in aged mice. These findings suggest that C-DIM activators of Nr4a transcription may be suitable to prevent memory deficits associated with aging.
Original language | English (US) |
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Pages (from-to) | 140-144 |
Number of pages | 5 |
Journal | Neurobiology of Aging |
Volume | 85 |
DOIs | |
State | Published - Jan 2020 |
Keywords
- Aging
- C-DIM drugs
- Nr4a
- Spatial memory
- Mice, Inbred C57BL
- Male
- Indoles/pharmacology
- Animals
- Memory Disorders/etiology
- Nuclear Receptor Subfamily 4, Group A, Member 1/genetics
- Spatial Memory/drug effects
- Transcription, Genetic/drug effects
- Cognitive Aging
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Aging
- General Neuroscience
- Developmental Biology