Pharmacokinetics of moxalactam in anuric children and during hemodialysis

Sheldon Kaplan, P. L. Berry, Edward Mason, W. G. Kramer

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Pharmacokinetics of moxalactam were determined in children with chronic renal failure during a 4-hour hemodialysis or an interdialytic period following a 50 mg/kg dose. Mean elimination half-life during dialysis was 3.9 hours compared to 12.9 hours during the interdialytic period. Mean clearance of moxalactam was 86 ml/minute during hemodialysis and 25 ml/minute between dialysis. Mean dialyzer clearance of moxalactam was 45 ml/minute. The mean fraction of moxalactam removed during a 4-hour hemodialysis was 18% in nine children. In anuric children, a 50 mg/kg dose of moxalactam should be given every 48 hours in an interdialytic period and a 25 mg/kg dose given after each dialysis.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalPediatric Pharmacology
Volume3
Issue number1
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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