TY - JOUR
T1 - Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression
AU - Letsou, George V.
AU - Safi, Hazim J.
AU - Reardon, Michael J.
AU - Ergenoglu, Mehmet
AU - Li, Zheng
AU - Klonaris, Christos N.
AU - Baldwin, John C.
AU - Gilbert, Brian E.
AU - Waldrep, John C.
N1 - Funding Information:
This work was supported by the Clayton Foundation for Research, Houston, TX, and Biotime, Inc., Berkeley, CA.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/12
Y1 - 1999/12
N2 - Background. The results of pulmonary transplantation are compromised by acute and chronic rejection. We hypothesized that a liposomal form of aerosolized cyclosporine A (CsA) would be selectively deposited and concentrated in the lungs. The theoretical advantage of this therapy is selective pulmonary immunosuppression with prolonged utilization. Methods. Eighteen dogs were endotracheally intubated; aerosolized liposomal CsA was administered for 15 min. CsA levels were measured in whole blood, lung, trachea, heart, kidney, liver, and spleen at various times after treatment. Results. The lung rapidly absorbs aerosolized liposomal CsA; other organs have much lower concentrations. The retention of pulmonary CsA delivered by liposome aerosol is approximately 120 min in this model. Conclusions. Aerosolized liposomal CsA is selectively deposited and concentrated in the lungs; other organs absorb less CsA.
AB - Background. The results of pulmonary transplantation are compromised by acute and chronic rejection. We hypothesized that a liposomal form of aerosolized cyclosporine A (CsA) would be selectively deposited and concentrated in the lungs. The theoretical advantage of this therapy is selective pulmonary immunosuppression with prolonged utilization. Methods. Eighteen dogs were endotracheally intubated; aerosolized liposomal CsA was administered for 15 min. CsA levels were measured in whole blood, lung, trachea, heart, kidney, liver, and spleen at various times after treatment. Results. The lung rapidly absorbs aerosolized liposomal CsA; other organs have much lower concentrations. The retention of pulmonary CsA delivered by liposome aerosol is approximately 120 min in this model. Conclusions. Aerosolized liposomal CsA is selectively deposited and concentrated in the lungs; other organs absorb less CsA.
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U2 - 10.1016/S0003-4975(99)01183-2
DO - 10.1016/S0003-4975(99)01183-2
M3 - Article
C2 - 10616974
AN - SCOPUS:0033386038
SN - 0003-4975
VL - 68
SP - 2044
EP - 2048
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 6
ER -