Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

Sheldon Kaplan; Edward Mason; Haydee Garcia; Sally J. Kvernland; Elaine M. Loiselle; Donald C. Anderson; A. Aaron Mintz; Ralph D. Feigin

doi:10.1016/S0022-3476(81)80562-8

Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

Sheldon Kaplan, Edward Mason, Haydee Garcia, Sally J. Kvernland, Elaine M. Loiselle, Donald C. Anderson, A. Aaron Mintz, Ralph D. Feigin

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Abstract

The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.

Original language	English (US)
Pages (from-to)	152-157
Number of pages	6
Journal	The Journal of Pediatrics
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(81)80562-8
State	Published - Jan 1981

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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@article{a695fde54c5f473181da0602624636ac,

title = "Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis",

abstract = "The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0\% (range 2.0 to 61\%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.",

author = "Sheldon Kaplan and Edward Mason and Haydee Garcia and Kvernland, \{Sally J.\} and Loiselle, \{Elaine M.\} and Anderson, \{Donald C.\} and Mintz, \{A. Aaron\} and Feigin, \{Ralph D.\}",

note = "Funding Information: From the Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine and the C. T. Parker Memorial Laboratory, Texas Children's Hospital, and Ben Taub General Hospital Supported by a grant from Lilly Research Laboratories, and by the Myers-Black Mellon Enterprises Pediatric Infectious Diseases Research Fund. *Reprint address: Division of Infectious Diseases, Texas Children's Hospital, 6621 Fannin, Houston, TX 77030. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1981",

month = jan,

doi = "10.1016/S0022-3476(81)80562-8",

language = "English (US)",

volume = "98",

pages = "152--157",

journal = "The Journal of Pediatrics",

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T1 - Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

AU - Kaplan, Sheldon

AU - Mason, Edward

AU - Garcia, Haydee

AU - Kvernland, Sally J.

AU - Loiselle, Elaine M.

AU - Anderson, Donald C.

AU - Mintz, A. Aaron

AU - Feigin, Ralph D.

N1 - Funding Information: From the Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine and the C. T. Parker Memorial Laboratory, Texas Children's Hospital, and Ben Taub General Hospital Supported by a grant from Lilly Research Laboratories, and by the Myers-Black Mellon Enterprises Pediatric Infectious Diseases Research Fund. *Reprint address: Division of Infectious Diseases, Texas Children's Hospital, 6621 Fannin, Houston, TX 77030. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1981/1

Y1 - 1981/1

N2 - The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.

AB - The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.

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Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

Abstract

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