Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

Sheldon Kaplan; Edward Mason; Haydee Garcia; Sally J. Kvernland; Elaine M. Loiselle; Donald C. Anderson; A. Aaron Mintz; Ralph D. Feigin

doi:10.1016/S0022-3476(81)80562-8

Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

Sheldon Kaplan, Edward Mason, Haydee Garcia, Sally J. Kvernland, Elaine M. Loiselle, Donald C. Anderson, A. Aaron Mintz, Ralph D. Feigin

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Research output: Contribution to journal › Article

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Abstract

The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.

Original language	English (US)
Pages (from-to)	152-157
Number of pages	6
Journal	The Journal of Pediatrics
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(81)80562-8
State	Published - Jan 1981

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis. / Kaplan, Sheldon; Mason, Edward; Garcia, Haydee; Kvernland, Sally J.; Loiselle, Elaine M.; Anderson, Donald C.; Mintz, A. Aaron; Feigin, Ralph D.

In: The Journal of Pediatrics, Vol. 98, No. 1, 01.1981, p. 152-157.

Research output: Contribution to journal › Article

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abstract = "The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.",

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