@article{a695fde54c5f473181da0602624636ac,
title = "Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis",
abstract = "The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.",
author = "Sheldon Kaplan and Edward Mason and Haydee Garcia and Kvernland, {Sally J.} and Loiselle, {Elaine M.} and Anderson, {Donald C.} and Mintz, {A. Aaron} and Feigin, {Ralph D.}",
note = "Funding Information: From the Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine and the C. T. Parker Memorial Laboratory, Texas Children's Hospital, and Ben Taub General Hospital Supported by a grant from Lilly Research Laboratories, and by the Myers-Black Mellon Enterprises Pediatric Infectious Diseases Research Fund. *Reprint address: Division of Infectious Diseases, Texas Children's Hospital, 6621 Fannin, Houston, TX 77030. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1981",
month = jan,
doi = "10.1016/S0022-3476(81)80562-8",
language = "English (US)",
volume = "98",
pages = "152--157",
journal = "The Journal of Pediatrics",
issn = "0022-3476",
publisher = "Elsevier",
number = "1",
}