Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

Sheldon Kaplan, Edward Mason, Haydee Garcia, Sally J. Kvernland, Elaine M. Loiselle, Donald C. Anderson, A. Aaron Mintz, Ralph D. Feigin

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalThe Journal of Pediatrics
Volume98
Issue number1
DOIs
StatePublished - Jan 1981

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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