PF4/heparin antibody testing and treatment of heparin-induced thrombocytopenia in the intensive care unit

Matthew Wanat, Kalliopi Fitousis, Jeff Hall, Lawrence Rice

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: The diagnosis of heparin-induced thrombocytopenia (HIT) may be challenging in critically ill patients, as heparin exposures are ubiquitous, and thrombocytopenia is common. Unwarranted ordering and incorrect interpretation of heparin antibody tests can expose a patient to adverse drug events and imposes a significant economic burden on our health care system. Methods: A prospective, observational study was performed over 4 months on all adult patients located in 5 intensive care units, with a heparin antibody test ordered. Results: A platelet factor 4/heparin enzyme-linked immunosorbent assay (ELISA) test was ordered in 131 patients. In total, 110 patients had a low 4Ts score (0-3), and of these 103 had a negative ELISA result. In patients with a low 4Ts score, 0 (0%) of 110 had an optical density value >1.0. One hundred twenty-nine patients (98%) had another possible cause of thrombocytopenia identified. Conclusion: In critically ill patients, low 4Ts scores indicate a low probability of HIT, and heparin antibody testing in these patients is not useful.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalClinical and Applied Thrombosis/Hemostasis
Volume19
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • heparin
  • heparin antibody test
  • heparin-induced thrombocytopenia
  • HIT
  • PF4/heparin
  • thrombocytopenia

ASJC Scopus subject areas

  • Hematology

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