Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants

Reuven Edri, Idan Gal, Nadav Noor, Tom Harel, Sharon Fleischer, Nofar Adadi, Ori Green, Doron Shabat, Lior Heller, Assaf Shapira, Irit Gat-Viks, Dan Peer, Tal Dvir

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Despite incremental improvements in the field of tissue engineering, no technology is currently available for producing completely autologous implants where both the cells and the scaffolding material are generated from the patient, and thus do not provoke an immune response that may lead to implant rejection. Here, a new approach is introduced to efficiently engineer any tissue type, which its differentiation cues are known, from one small tissue biopsy. Pieces of omental tissues are extracted from patients and, while the cells are reprogrammed to become induced pluripotent stem cells, the extracellular matrix is processed into an immunologically matching, thermoresponsive hydrogel. Efficient cell differentiation within a large 3D hydrogel is reported, and, as a proof of concept, the generation of functional cardiac, cortical, spinal cord, and adipogenic tissue implants is demonstrated. This versatile bioengineering approach may assist to regenerate any tissue and organ with a minimal risk for immune rejection.

Original languageEnglish (US)
Article number1803895
JournalAdvanced Materials
Volume31
Issue number1
DOIs
StatePublished - Jan 4 2019

Keywords

  • autologous
  • decellularized hydrogels
  • induced pluripotent stem cells
  • non-immunogenic
  • tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants'. Together they form a unique fingerprint.

Cite this