Personalized drug testing of tumor samples using a microfluidic platform

Adán D. Rodríguez, Lisa Horowitz, Maxwell Rumaner, Vijayakrishna K. Gadi, Raymond Monnat, Robert C. Rostomily, Albert Folch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This manuscript reports a user-friendly microfluidic platform for parallel chemosensitivity testing of live patient tissue, which we refer to as Oncoslice [1]. Oncoslice would identify a subset of therapies with the greatest potential for individual patients in a time frame appropriate for therapeutic decision-making and personalized medicine. Here we present a redesigned architecture of Oncoslice and new manufacturing techniques that will facilitate its fabrication on the larger scale necessary for clinical use. We extend our prior studies with normal mouse tissues to include testing with patient-derived glioma xenografts and clinical breast cancer biopsy samples.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages235-236
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Other

Other21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • Cancer Therapeutics
  • Personalized Medicine
  • Translational Medicine

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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