Abstract
This manuscript reports a user-friendly microfluidic platform for parallel chemosensitivity testing of live patient tissue, which we refer to as Oncoslice [1]. Oncoslice would identify a subset of therapies with the greatest potential for individual patients in a time frame appropriate for therapeutic decision-making and personalized medicine. Here we present a redesigned architecture of Oncoslice and new manufacturing techniques that will facilitate its fabrication on the larger scale necessary for clinical use. We extend our prior studies with normal mouse tissues to include testing with patient-derived glioma xenografts and clinical breast cancer biopsy samples.
Original language | English (US) |
---|---|
Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
Publisher | Chemical and Biological Microsystems Society |
Pages | 235-236 |
Number of pages | 2 |
ISBN (Electronic) | 9780692941836 |
State | Published - Jan 1 2020 |
Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017 |
Other
Other | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
---|---|
Country | United States |
City | Savannah |
Period | 10/22/17 → 10/26/17 |
Keywords
- Cancer Therapeutics
- Personalized Medicine
- Translational Medicine
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering