Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight

Thomas H. Mader; C. Robert Gibson; Michael R. Barratt; Neil R. Miller; Prem S. Subramanian; Hanspeter E. Killer; William J. Tarver; Ashot E. Sargsyan; Kathleen Garcia; Stephen F. Hart; Larry A. Kramer; Roy Riascos; Tyson J. Brunstetter; William Lipsky; Peter Wostyn; Andrew G. Lee

doi:10.1080/01658107.2020.1791189

Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight

Thomas H. Mader, C. Robert Gibson, Michael R. Barratt, Neil R. Miller, Prem S. Subramanian, Hanspeter E. Killer, William J. Tarver, Ashot E. Sargsyan, Kathleen Garcia, Stephen F. Hart, Larry A. Kramer, Roy Riascos, Tyson J. Brunstetter, William Lipsky, Peter Wostyn, Andrew G. Lee

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Posterior globe flattening has been well-documented in astronauts both during and after long-duration space flight (LDSF) and has been observed as early as 10 days into a mission on the International Space Station. Globe flattening (GF) is thought to be caused by the disc centred anterior forces created by elevated volume and/or pressure within the optic nerve sheath (ONS). This might be the result of increased intracranial pressure, increased intraorbital ONS pressure from compartmentalisation or a combination of these mechanisms. We report posterior GF in three astronauts that has persisted for 7 years or more following their return from LDSFs suggesting that permanent scleral remodelling may have occurred.

Original language	English (US)
Pages (from-to)	29-35
Number of pages	7
Journal	Neuro-Ophthalmology
Volume	45
Issue number	1
Early online date	Sep 3 2020
DOIs	https://doi.org/10.1080/01658107.2020.1791189
State	Published - 2021

Keywords

SANS
astronaut
hyperopic shift
international space station (ISS)
long-duration space flight (LDSF)
visual changes

ASJC Scopus subject areas

Ophthalmology
Clinical Neurology

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10.1080/01658107.2020.1791189

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Mader, T. H., Gibson, C. R., Barratt, M. R., Miller, N. R., Subramanian, P. S., Killer, H. E., Tarver, W. J., Sargsyan, A. E., Garcia, K., Hart, S. F., Kramer, L. A., Riascos, R., Brunstetter, T. J., Lipsky, W., Wostyn, P., & Lee, A. G. (2021). Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight. Neuro-Ophthalmology, 45(1), 29-35. https://doi.org/10.1080/01658107.2020.1791189

Mader, TH, Gibson, CR, Barratt, MR, Miller, NR, Subramanian, PS, Killer, HE, Tarver, WJ, Sargsyan, AE, Garcia, K, Hart, SF, Kramer, LA, Riascos, R, Brunstetter, TJ, Lipsky, W, Wostyn, P & Lee, AG 2021, 'Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight', Neuro-Ophthalmology, vol. 45, no. 1, pp. 29-35. https://doi.org/10.1080/01658107.2020.1791189

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abstract = "Posterior globe flattening has been well-documented in astronauts both during and after long-duration space flight (LDSF) and has been observed as early as 10 days into a mission on the International Space Station. Globe flattening (GF) is thought to be caused by the disc centred anterior forces created by elevated volume and/or pressure within the optic nerve sheath (ONS). This might be the result of increased intracranial pressure, increased intraorbital ONS pressure from compartmentalisation or a combination of these mechanisms. We report posterior GF in three astronauts that has persisted for 7 years or more following their return from LDSFs suggesting that permanent scleral remodelling may have occurred.",

keywords = "SANS, astronaut, hyperopic shift, international space station (ISS), long-duration space flight (LDSF), visual changes",

author = "Mader, \{Thomas H.\} and Gibson, \{C. Robert\} and Barratt, \{Michael R.\} and Miller, \{Neil R.\} and Subramanian, \{Prem S.\} and Killer, \{Hanspeter E.\} and Tarver, \{William J.\} and Sargsyan, \{Ashot E.\} and Kathleen Garcia and Hart, \{Stephen F.\} and Kramer, \{Larry A.\} and Roy Riascos and Brunstetter, \{Tyson J.\} and William Lipsky and Peter Wostyn and Lee, \{Andrew G.\}",

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AU - Killer, Hanspeter E.

AU - Tarver, William J.

AU - Sargsyan, Ashot E.

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AU - Hart, Stephen F.

AU - Kramer, Larry A.

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AB - Posterior globe flattening has been well-documented in astronauts both during and after long-duration space flight (LDSF) and has been observed as early as 10 days into a mission on the International Space Station. Globe flattening (GF) is thought to be caused by the disc centred anterior forces created by elevated volume and/or pressure within the optic nerve sheath (ONS). This might be the result of increased intracranial pressure, increased intraorbital ONS pressure from compartmentalisation or a combination of these mechanisms. We report posterior GF in three astronauts that has persisted for 7 years or more following their return from LDSFs suggesting that permanent scleral remodelling may have occurred.

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KW - hyperopic shift

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Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight

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