Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium

Hui Sun; Debra J. Gilbert; Neal G. Copeland; Nancy A. Jenkins; Jeremy Nathans

doi:10.1073/pnas.94.18.9893

Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium

Hui Sun, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Jeremy Nathans

Research output: Contribution to journal › Article

113 Scopus citations

Abstract

A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

Original language	English (US)
Pages (from-to)	9893-9898
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	94
Issue number	18
DOIs	https://doi.org/10.1073/pnas.94.18.9893
State	Published - Sep 2 1997

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Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. / Sun, Hui; Gilbert, Debra J.; Copeland, Neal G.; Jenkins, Nancy A.; Nathans, Jeremy.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 18, 02.09.1997, p. 9893-9898.

Research output: Contribution to journal › Article

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abstract = "A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.",

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