Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues

Noninvasive cardiovascular imaging could lead to the early detection and timely treatment of complex atherosclerotic lesions responsible for major cardiovascular events. Recent investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool due to the high resolution this technology achieves in discriminating the different features of atherosclerotic lesions based on structural imaging. We explore the capability of OCT for functional imaging of normal and atherosclerotic aortic tissues based on time- and depth-resolved quantification of the permeability of biomolecules through these tissues. The permeability coefficient of 20% aqueous solution of glucose was found to be (6.80±0.18)×10 ^-6cm/s in normal aortas and (2.69±0.42)×10 ^-5cm/s in aortas with atherosclerotic disease. The results suggest that this new OCT functional imaging method - the assessment of the permeability coefficients of various physiologically neutral biomolecules in vascular tissues - could assist in early diagnosing and detecting the different components of atherosclerotic lesions.