Perivascular epithelioid cell tumor of the uterus: Immunohistochemical, ultrastructural and molecular study

Sung Hye Park, Jae Ro, Han Seong Kim, Eung Soo Lee

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A case of perivascular epithelioid cell tumor of the uterus is reported, occurring in a 32-year-old woman. The tumor (8.0 cm in dimension) showed exophytic growth from the outer half of the myometrium. Histopathologically, the tumor was composed of thick blood vessels and perivascular epithelioid cells. The neoplastic cells were strongly immunoreactlve for HMB45 antigen, CD117 (c-kit), vimentin and the progesterone receptor, but completely negative for S-100 protein, smooth muscle actin, desmin, CD34, the estrogen receptor and p16. The Ki-67 labeling index was low (1.25%). Ultrastructurally, the neoplastlc cells had numerous premelanosomes with some glycogen deposits. Single-stranded DNA conformational polymorphism of p53 and methylation-specific polymerase chain reaction of p16 revealed negative results. Definite melanosomes on electron microscopic analysis and coexpresslon of HMB45 antigen and stem cell factor receptor (CD117) may provide the clue to understanding perivascular epithelioid cell tumor because angiomyolipoma also coexpresses HMB45 antigen and CD117.

Original languageEnglish (US)
Pages (from-to)800-805
Number of pages6
JournalPathology International
Volume53
Issue number11
DOIs
StatePublished - Nov 1 2003

Keywords

  • CD117 (c-kit)
  • HMB45 antigen
  • Melanosomes
  • Perivascular epithelioid cells
  • Uterus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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