TY - JOUR
T1 - PERIPHERAL RETINAL ANGIOGRAPHIC FINDINGS IN MACULAR TELANGIECTASIS TYPE 2
AU - Moysidis, Stavros N.
AU - Koulisis, Nicole
AU - Rao, Prethy
AU - Govindaraju, Viren K.
AU - Gamsky, Samuel
AU - Mahmoud, Tamer H.
AU - Randhawa, Sandeep
AU - Faia, Lisa J.
AU - Wolfe, Jeremy D.
AU - Drenser, Kimberly A.
AU - Ruby, Alan J.
AU - Garretson, Bruce R.
AU - Hassan, Tarek S.
AU - Williams, George A.
AU - Trese, Michael T.
AU - Capone, Antonio
N1 - Funding Information:
Supported by unrestricted grants from the Alliance for Vision Research, Southfield, MI, Research to Prevent Blindness, New York, NY, and by the generous support of the Heed Ophthalmic Foundation and the Ronald G. Michels Foundation. The sponsors had no role in the design or conduct of this research.
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Purpose:To evaluate the retinal periphery in patients with idiopathic juxtafoveal telangiectasis or macular telangiectasis Type 2 (MacTel2), using widefield fluorescein angiography.Methods:Single-center, retrospective, observational case series of 50 eyes of 50 patients with MacTel2 and 50 eyes of 50 age-matched controls.Results:Thirty-seven eyes in the MacTel2 group (74%) showed peripheral capillary nonperfusion or dropout, compared with 37 eyes in the control group (74%, P = 1.0). Morphologically, the MacTel2 group trended toward having a higher proportion of pruning-type capillary dropout (44%) compared with controls (28%), but this was not statistically significant (P = 0.12). Patients with MacTel2 had a higher incidence of microaneurysms compared with controls (MacTel2 56%; controls 42%; P = 0.048), independent of age or systemic risk factors. There was no difference in the incidence of venous-venous shunts (MacTel2 10%; controls 10%; P = 1.0), arteriovenous shunts (MacTel2 14%; controls 18%; P = 0.60), venous tortuosity (MacTel2 60%; controls 66%; P = 0.58), or arterial tortuosity (MacTel2 54%; controls 68%; P = 0.20), which was mild in most cases.Conclusion:We note a high incidence of peripheral vascular and retinal findings in both patients with MacTel2 and age-matched controls, using widefield fluorescein angiography. Patients with MacTel2 had significantly more microaneurysms, independent of age or other systemic risk factors.
AB - Purpose:To evaluate the retinal periphery in patients with idiopathic juxtafoveal telangiectasis or macular telangiectasis Type 2 (MacTel2), using widefield fluorescein angiography.Methods:Single-center, retrospective, observational case series of 50 eyes of 50 patients with MacTel2 and 50 eyes of 50 age-matched controls.Results:Thirty-seven eyes in the MacTel2 group (74%) showed peripheral capillary nonperfusion or dropout, compared with 37 eyes in the control group (74%, P = 1.0). Morphologically, the MacTel2 group trended toward having a higher proportion of pruning-type capillary dropout (44%) compared with controls (28%), but this was not statistically significant (P = 0.12). Patients with MacTel2 had a higher incidence of microaneurysms compared with controls (MacTel2 56%; controls 42%; P = 0.048), independent of age or systemic risk factors. There was no difference in the incidence of venous-venous shunts (MacTel2 10%; controls 10%; P = 1.0), arteriovenous shunts (MacTel2 14%; controls 18%; P = 0.60), venous tortuosity (MacTel2 60%; controls 66%; P = 0.58), or arterial tortuosity (MacTel2 54%; controls 68%; P = 0.20), which was mild in most cases.Conclusion:We note a high incidence of peripheral vascular and retinal findings in both patients with MacTel2 and age-matched controls, using widefield fluorescein angiography. Patients with MacTel2 had significantly more microaneurysms, independent of age or other systemic risk factors.
KW - JXT
KW - MacTel2
KW - aging
KW - idiopathic parafoveal juxtafoveal telangiectasis
KW - macular telangiectasis Type 2
KW - multimodal imaging
KW - ocular manifestations of systemic disease
KW - optical coherence tomography
KW - retinal periphery
KW - retinal vascular pathology
KW - widefield fluorescein angiography
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U2 - 10.1097/IAE.0000000000002981
DO - 10.1097/IAE.0000000000002981
M3 - Article
C2 - 32969983
AN - SCOPUS:85102212334
SN - 0275-004X
VL - 41
SP - 480
EP - 486
JO - Retina
JF - Retina
IS - 3
ER -