Stavros N. Moysidis, Nicole Koulisis, Prethy Rao, Viren K. Govindaraju, Samuel Gamsky, Tamer H. Mahmoud, Sandeep Randhawa, Lisa J. Faia, Jeremy D. Wolfe, Kimberly A. Drenser, Alan J. Ruby, Bruce R. Garretson, Tarek S. Hassan, George A. Williams, Michael T. Trese, Antonio Capone

Research output: Contribution to journalArticlepeer-review


Purpose:To evaluate the retinal periphery in patients with idiopathic juxtafoveal telangiectasis or macular telangiectasis Type 2 (MacTel2), using widefield fluorescein angiography.Methods:Single-center, retrospective, observational case series of 50 eyes of 50 patients with MacTel2 and 50 eyes of 50 age-matched controls.Results:Thirty-seven eyes in the MacTel2 group (74%) showed peripheral capillary nonperfusion or dropout, compared with 37 eyes in the control group (74%, P = 1.0). Morphologically, the MacTel2 group trended toward having a higher proportion of pruning-type capillary dropout (44%) compared with controls (28%), but this was not statistically significant (P = 0.12). Patients with MacTel2 had a higher incidence of microaneurysms compared with controls (MacTel2 56%; controls 42%; P = 0.048), independent of age or systemic risk factors. There was no difference in the incidence of venous-venous shunts (MacTel2 10%; controls 10%; P = 1.0), arteriovenous shunts (MacTel2 14%; controls 18%; P = 0.60), venous tortuosity (MacTel2 60%; controls 66%; P = 0.58), or arterial tortuosity (MacTel2 54%; controls 68%; P = 0.20), which was mild in most cases.Conclusion:We note a high incidence of peripheral vascular and retinal findings in both patients with MacTel2 and age-matched controls, using widefield fluorescein angiography. Patients with MacTel2 had significantly more microaneurysms, independent of age or other systemic risk factors.

Original languageEnglish (US)
Pages (from-to)480-486
Number of pages7
Issue number3
StatePublished - Mar 1 2021


  • JXT
  • MacTel2
  • aging
  • idiopathic parafoveal juxtafoveal telangiectasis
  • macular telangiectasis Type 2
  • multimodal imaging
  • ocular manifestations of systemic disease
  • optical coherence tomography
  • retinal periphery
  • retinal vascular pathology
  • widefield fluorescein angiography

ASJC Scopus subject areas

  • Ophthalmology


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