Peripheral neuropathy secondary to docetaxel (Taxotere)

P. Z. New, C. E. Jackson, D. Rinaldi, H. Burris, R. J. Barohn

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Docetaxel (Taxotere), a semisynthetic analogue of the antitumor agent paclitaxel, inhibits tubulin depolymerization. Paclitaxel produces a peripheral neuropathy. This study delineates clinically and electrophysiologically the characteristics of a peripheral neuropathy due to docetaxel. In 186 patients receiving docetaxel in phase I or phase II protocols, we performed serial neurologic exams. As patients became symptomatic, quantitative sensory testing and nerve conduction studies were done. Twenty-one patients developed mild to moderate sensory neuropathy on taxotere at a wide range of cumulative doses (50 to 750 mg/m2) and dose levels (10 to 115 mg/m2). Ten of these patients also developed weakness of varying degree in proximal and distal extremities. Nine of the 21 patients had received neurotoxic chemotherapy before; 16 were treated with docetaxel at a dose level of 100 to 115 mg/m2. In summary, docetaxel produced a sensorimotor peripheral neuropathy in 11% of our patient population.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalNeurology
Volume46
Issue number1
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Peripheral neuropathy secondary to docetaxel (Taxotere)'. Together they form a unique fingerprint.

Cite this