Peripheral lung cancer detection by vascular tumor labeling using in-vivo microendoscopy under real time 3D CT image guided intervention

Miguel Valdivia y Alvarado, Tian Cheng He, Zhong Xue, Stephen T. Wong, Kelvin Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We designed and evaluated a real time 3D CT Image Guided Intervention system that integrates in-vivo microendoscopic imaging for on-the-spot visualization of ICG contrast uptake by tumor vessel in peripheral lung tumors. The performance of the system was evaluated in seven rabbits where VX2 cells were implanted in the chest to create peripheral lung tumors. Two weeks later the animal underwent a chest CT scan which was used for creating a real time 3D vision and navigation tracking. ICG was injected fifteen minutes prior to the needle puncture to allow adequate contrast leakage inside the tumor and plasma clearance. After the needle puncture, the microendoscope was introduced inside the tumor for imaging. Visualization of tumor leaky vasculature was possible in all the tumors. The experiment demonstrated that real-time microendoscopy of deep solid organs under a 3D CT image-guided system is possible while providing enough accuracy in reaching tumors without complications.

Original languageEnglish (US)
Title of host publicationMedical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings
Pages494-502
Number of pages9
DOIs
StatePublished - Nov 9 2010
Event5th International Workshop on Medical Imaging and Augmented Reality, MIAR 2010 - Beijing, China
Duration: Sep 19 2010Sep 20 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6326 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other5th International Workshop on Medical Imaging and Augmented Reality, MIAR 2010
CountryChina
CityBeijing
Period9/19/109/20/10

Keywords

  • Indocyanine Green (ICG)
  • Lung Cancer Detection
  • Microendoscopy
  • Real Time 3D CT Image Guided Intervention
  • Tumor Leaky Vasculature

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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