TY - GEN
T1 - Peripheral lung cancer detection by vascular tumor labeling using in-vivo microendoscopy under real time 3D CT image guided intervention
AU - Valdivia y Alvarado, Miguel
AU - Cheng He, Tian
AU - Xue, Zhong
AU - Wong, Stephen T.
AU - Wong, Kelvin
PY - 2010/11/9
Y1 - 2010/11/9
N2 - We designed and evaluated a real time 3D CT Image Guided Intervention system that integrates in-vivo microendoscopic imaging for on-the-spot visualization of ICG contrast uptake by tumor vessel in peripheral lung tumors. The performance of the system was evaluated in seven rabbits where VX2 cells were implanted in the chest to create peripheral lung tumors. Two weeks later the animal underwent a chest CT scan which was used for creating a real time 3D vision and navigation tracking. ICG was injected fifteen minutes prior to the needle puncture to allow adequate contrast leakage inside the tumor and plasma clearance. After the needle puncture, the microendoscope was introduced inside the tumor for imaging. Visualization of tumor leaky vasculature was possible in all the tumors. The experiment demonstrated that real-time microendoscopy of deep solid organs under a 3D CT image-guided system is possible while providing enough accuracy in reaching tumors without complications.
AB - We designed and evaluated a real time 3D CT Image Guided Intervention system that integrates in-vivo microendoscopic imaging for on-the-spot visualization of ICG contrast uptake by tumor vessel in peripheral lung tumors. The performance of the system was evaluated in seven rabbits where VX2 cells were implanted in the chest to create peripheral lung tumors. Two weeks later the animal underwent a chest CT scan which was used for creating a real time 3D vision and navigation tracking. ICG was injected fifteen minutes prior to the needle puncture to allow adequate contrast leakage inside the tumor and plasma clearance. After the needle puncture, the microendoscope was introduced inside the tumor for imaging. Visualization of tumor leaky vasculature was possible in all the tumors. The experiment demonstrated that real-time microendoscopy of deep solid organs under a 3D CT image-guided system is possible while providing enough accuracy in reaching tumors without complications.
KW - Indocyanine Green (ICG)
KW - Lung Cancer Detection
KW - Microendoscopy
KW - Real Time 3D CT Image Guided Intervention
KW - Tumor Leaky Vasculature
UR - http://www.scopus.com/inward/record.url?scp=78049444978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049444978&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-15699-1_52
DO - 10.1007/978-3-642-15699-1_52
M3 - Conference contribution
AN - SCOPUS:78049444978
SN - 3642156983
SN - 9783642156984
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 494
EP - 502
BT - Medical Imaging and Augmented Reality - 5th International Workshop, MIAR 2010, Proceedings
T2 - 5th International Workshop on Medical Imaging and Augmented Reality, MIAR 2010
Y2 - 19 September 2010 through 20 September 2010
ER -