Peripheral biphasic adenocarcinoma of the lung: Light microscopic and immunohistochemical findings

Philip T. Cagle, Lesley C. Alpert, Pedro A. Carmona

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We report two cases of peripheral biphasic adenocarcinoma primary in the lung. To our knowledge, peripheral adenocarcinoma of the lung with a spindle-cell compoment has not been described previously. Diffuse positive cytokeratin and negative vimentin immunostaining of the spindle-cell components support an epithelial differentiation of the malignant spindle cells. Although study of additional cases is needed, our initial findings suggest that immunohistochemical staining pattern may help distinguish these neoplasms from other biphasic neoplasms primary or secondary to the lung, such as carcinosarcoma or malignant mesothelioma.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalHuman Pathology
Volume23
Issue number2
DOIs
StatePublished - Jan 1 1992

Keywords

  • adenocarcinoma
  • cytokeratin
  • immunohistochemistry
  • lung cancer
  • spindle-cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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