Perioperative care differences of surgical aortic valve replacement between North America and Europe

Bart J.J. Velders, Michiel D. Vriesendorp, Rob A.F. De Lind Van Wijngaarden, Vivek Rao, Michael J. Reardon, Malakh Shrestha, Michael W.A. Chu, Joseph F. Sabik, Fang Liu, Robert J.M. Klautz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective To describe differences between North America and Europe in the perioperative management of patients undergoing surgical aortic valve replacement (SAVR). Methods Patients with moderate or greater aortic stenosis or regurgitation requiring SAVR were enrolled in a prospective observational cohort evaluating the safety and efficacy of a new stented bioprosthesis at 25 centres in North America (Canada and the USA) and 13 centres in Europe (Germany, the Netherlands, France, the UK, Switzerland and Italy). While all patients underwent implantation with the same bioprosthetic model, perioperative management was left to the discretion of participating centres. Perioperative care was described in detail including outcomes up to 1-year follow-up. Results Among 1118 patients, 643 (58%) were implanted in North America, and 475 (42%) were implanted in Europe. Patients in Europe were older, had a lower body mass index, less bicuspid disease and worse degree of aortic stenosis at baseline. In Europe, anticoagulant therapy at discharge was more aggressive, whereas length of stay was longer, and discharges directly to home were less common. Rehospitalisation risk was lower in Europe at 30 days (8.5% vs 15.9%) but converged at 1-year follow-up (26.5% vs 28.1%). Within continents, there were major differences between individual countries concerning perioperative management. Conclusion Contemporary perioperative management of SAVR patients varies between North America and Europe in patient selection, procedural techniques, antithrombotic regimen and discharge management. Furthermore, rehospitalisation differed largely between continents and countries. Hence, geographical setting must be considered during design and interpretation of trials on SAVR. Trial registration number NCT02088554.

Original languageEnglish (US)
Pages (from-to)1106-1112
Number of pages7
Issue number14
StatePublished - Jun 26 2023


  • aortic valve insufficiency
  • aortic valve stenosis
  • health care economics and organizations
  • heart valve prosthesis implantation
  • Perioperative Care
  • Humans
  • Risk Factors
  • Treatment Outcome
  • Heart Valve Prosthesis/adverse effects
  • Transcatheter Aortic Valve Replacement/methods
  • Heart Valve Prosthesis Implantation/adverse effects
  • Europe/epidemiology
  • Aortic Valve Stenosis/surgery
  • Aortic Valve/surgery
  • North America/epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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