5 Scopus citations


Basosquamous carcinoma is a rare, highly aggressive variant of basal cell carcinoma with elevated rates of recurrence, perineural invasion, and metastasis. We describe a patient who presented with unilateral complete ophthalmoplegia, ptosis, optic neuropathy, and trigeminal neuropathy due to perineural intracranial invasion of nasal basosquamous carcinoma via the sphenopalatine fossa to the cavernous sinus, orbit, and infratemporal fossa. To our knowledge, this is the first reported case of basosquamous carcinoma with perineural invasion involving the cavernous sinus in the English language ophthalmic literature. Physicians should be aware of the diagnostic features, clinical challenges and aggressive nature of basosquamous carcinoma, a rare diagnosis that can lead to significant morbidity/mortality when left unrecognized.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalOrbit (London)
Issue number2
StatePublished - Mar 4 2018


  • Squamous cell carcinoma
  • basal cell carcinoma
  • basosquamous carcinoma
  • ophthalmoplegia
  • perineural invasion

ASJC Scopus subject areas

  • Ophthalmology


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