Abstract
Interferon gamma release assays (IGRAs) are poorly studied in HIV-infected children. The authors prospectively evaluated QuantiFERON-TB Gold results and family-described tuberculosis (TB) risk factors in 100 HIV-infected children in Botswana. Median age was 10.2 years; 58 were girls, 92 had received the Bacillus Calmette-Guérin (BCG) vaccine, 98 were receiving antiretroviral therapy, and the median body mass index was 15.8 kg/m2. Eighty-nine children had undetectable viral loads and the median CD4 count was 962 cells/mm3. Eighteen children had been treated for TB in the last 3 years. In the last 3 years, 36 (including 9 with TB) had contact with persons with TB (26 within/15 outside the home and 5 had >1 contact). In all, 96 children had negative IGRAs, 3 were indeterminate, and 1 was positive. The positive IGRA was reported in a child treated for TB prior to 3 years. Interferon γ release assay positivity was rare in this pediatric cohort living in an area with a high prevalence of TB.
Original language | English (US) |
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Pages (from-to) | 4-7 |
Number of pages | 4 |
Journal | Journal of the International Association of Providers of AIDS Care |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Jan 21 2015 |
Keywords
- HIV
- interferon gamma release assay
- latent tuberculosis infection
- prevention
- tuberculosis
- tuberculosis risk factors
ASJC Scopus subject areas
- Immunology
- Dermatology
- Infectious Diseases