@article{dc48dc1581bf40239af183c5bdaca3e4,
title = "Performance of glomerular filtration rate estimating equations in a community-based sample of Blacks and Whites: The multiethnic study of atherosclerosis",
abstract = "Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are recommended for glomerular filtration rate (GFR) estimation in the general population. They have not been evaluated in community-based populations, including Blacks at higher levels of GFR, but are commonly applied in such populations. Methods In an ancillary study of Multi-Ethnic Study of Atherosclerosis conducted at one site, we evaluated the performance of the CKD-EPI equations for creatinine (eGFRcr), cystatin C (eGFRcys) or the combination (eGFRcr-cys) compared with GFR measured as plasma clearance of iohexol. Results Among 294 participants, the mean age was 71 (SD 9) years, 47% were Black, 48% were women and the mean measured GFR (mGFR) was 72.6 (SD 18.8) mL/min/1.73 m 2. The CKD-EPI equations overestimated mGFR with a larger median bias for eGFRcr and eGFRcr-cys than eGFRcys [-8.3 (95% confidence interval -9.7, -6.5), -7.8 (-9.2, -6.2) and -3.7 (-5.0, -1.8) mL/min/1.73 m 2, respectively], with smaller bias for those with lower compared with higher eGFR and by race compared with sex. Conclusion The small differential bias of the CKD-EPI equation between races suggests that they can be used in Blacks as well as Whites in older community-based adults. The large differential bias in women versus men in all equations is in contrast to other studies and is unexplained. Further studies are required in multiracial and multiethnic community-based cohorts, taking into account differences in GFR measurement methods.",
keywords = "creatinine, cystatin C, glomerular filtration rate, multiethnic study of atherosclerosis",
author = "Inker, {Lesley A.} and Levey, {Andrew S.} and Hocine Tighiouart and Tariq Shafi and Eckfeldt, {John H.} and Craig Johnson and Aghogho Okparavero and Post, {Wendy S.} and Josef Coresh and Shlipak, {Michael G.}",
note = "Funding Information: L.A.I. reports funding to Tufts Medical Center for research and contracts with the National Institutes of Health, National Funding Information: This research was supported by a grant from the National Institutes of Health (R01DK087961, contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169); the National Heart, Lung, and Blood Institute and National Center for Research Resources (UL1-TR-000040 and UL1-TR-001079). Funding Information: Kidney Foundation, Pharmalink, Gilead Sciences and Otsuka. A.S.L. reports funding to Tufts Medical Center for research and contracts with the National Institutes of Health, National Kidney Foundation, Amgen, Pharmalink, Gilead Sciences and Otsuka. J.C. reports funding to Johns Hopkins University for research and contracts with the National Institutes of Health and the National Kidney Foundation. J.H.E. is a consultant to Gentian, Moss, Norway. Siemens Healthcare Diagnostics, Tarrytown, NY, has provided free or steeply discounted reagents for studies performed in J.H.E.{\textquoteright}s research laboratory. He also receives funding from the National Institutes of Health, the Centers for Disease Control and Prevention and several private research foundations. M.G.S. receives funding from the National Institutes of Health and serves as an advisor to Cricket Health and to Tai Diagnostics. T.S. and W.S.P. receive funding from the National Institutes of Health. H.T., C.J. and A.O. declare that they have no conflicts of interest. Publisher Copyright: {\textcopyright} 2017 The Author.",
year = "2018",
month = mar,
day = "1",
doi = "10.1093/ndt/gfx042",
language = "English (US)",
volume = "33",
pages = "417--425",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "3",
}