Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

Tianjiao Ji; Yanping Ding; Ying Zhao; Jing Wang; Hao Qin; Xiaoman Liu; Jiayan Lang; Ruifang Zhao; Yinlong Zhang; Jian Shi; Ning Tao; Zhihai Qin; Guangjun Nie

doi:10.1002/adma.201404715

Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

Tianjiao Ji, Yanping Ding, Ying Zhao, Jing Wang, Hao Qin, Xiaoman Liu, Jiayan Lang, Ruifang Zhao, Yinlong Zhang, Jian Shi, Ning Tao, Zhihai Qin, Guangjun Nie

Houston Methodist

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake.

Original language	English (US)
Pages (from-to)	1865-1873
Number of pages	9
Journal	Advanced Materials
Volume	27
Issue number	11
DOIs	https://doi.org/10.1002/adma.201404715
State	Published - Mar 18 2015

Keywords

cancer-associated fibroblast
cell-penetrating peptide
drug delivery
tumor penetration

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201404715

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title = "Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery",

abstract = "An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake.",

keywords = "cancer-associated fibroblast, cell-penetrating peptide, drug delivery, tumor penetration",

author = "Tianjiao Ji and Yanping Ding and Ying Zhao and Jing Wang and Hao Qin and Xiaoman Liu and Jiayan Lang and Ruifang Zhao and Yinlong Zhang and Jian Shi and Ning Tao and Zhihai Qin and Guangjun Nie",

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TY - JOUR

T1 - Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

AU - Ji, Tianjiao

AU - Ding, Yanping

AU - Zhao, Ying

AU - Wang, Jing

AU - Qin, Hao

AU - Liu, Xiaoman

AU - Lang, Jiayan

AU - Zhao, Ruifang

AU - Zhang, Yinlong

AU - Shi, Jian

AU - Tao, Ning

AU - Qin, Zhihai

AU - Nie, Guangjun

PY - 2015/3/18

Y1 - 2015/3/18

N2 - An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake.

AB - An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake.

KW - cancer-associated fibroblast

KW - cell-penetrating peptide

KW - drug delivery

KW - tumor penetration

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JO - Advanced Materials

JF - Advanced Materials

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ER -

Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

Abstract

Keywords

ASJC Scopus subject areas

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