Abstract
An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake.
Original language | English (US) |
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Pages (from-to) | 1865-1873 |
Number of pages | 9 |
Journal | Advanced Materials |
Volume | 27 |
Issue number | 11 |
DOIs | |
State | Published - Mar 18 2015 |
Keywords
- cancer-associated fibroblast
- cell-penetrating peptide
- drug delivery
- tumor penetration
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering