Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

Tianjiao Ji, Yanping Ding, Ying Zhao, Jing Wang, Hao Qin, Xiaoman Liu, Jiayan Lang, Ruifang Zhao, Yinlong Zhang, Jian Shi, Ning Tao, Zhihai Qin, Guangjun Nie

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake.

Original languageEnglish (US)
Pages (from-to)1865-1873
Number of pages9
JournalAdvanced Materials
Volume27
Issue number11
DOIs
StatePublished - Mar 18 2015

Keywords

  • cancer-associated fibroblast
  • cell-penetrating peptide
  • drug delivery
  • tumor penetration

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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