Penicillin resistance and serotypes/serogroups of Streptococcus pneumoniae in nasopharyngeal carrier children younger than 2 years in Lima, Peru

Theresa J. Ochoa, Rocio Rupa, Humberto Guerra, Herminio Hernandez, Eduardo Chaparro, Jesus Tamariz, Audrey Wanger, Edward O. Mason

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The purpose of this study was to determine the carriage rate, susceptibility pattern, and serotype distribution of Streptococcus pneumoniae in the nasopharynx of children younger than 2 years old in Lima, Peru. A total of 666 children were evaluated during 3 periods, 1997, 2001, and 2003. The overall pneumococcal carrier rate was 41%. Reduced susceptibility to penicillin was found in 5% (4/75) of isolates in 1997, 20% (15/75) in 2001, and 37% (40/109) in 2003. Reduced susceptibility to ceftriaxone was found in 12% of isolates in 2003. Serogroups 6, 19, 23, 15, and 14 accounted for 68% of all the isolates and for 81% of the penicillin-nonsusceptible strains. Only 65% of the isolated strains had serogroups found in the 7-valent conjugate pneumococcal vaccine. This highlights the importance of regional surveillance studies for effective vaccine strategies and treatment protocols.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume52
Issue number1
DOIs
StatePublished - May 2005

Keywords

  • Lima, Peru
  • Penicillin resistance
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Virology
  • Parasitology
  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology

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