TY - JOUR
T1 - Penicillin resistance and serotypes/serogroups of Streptococcus pneumoniae in nasopharyngeal carrier children younger than 2 years in Lima, Peru
AU - Ochoa, Theresa J.
AU - Rupa, Rocio
AU - Guerra, Humberto
AU - Hernandez, Herminio
AU - Chaparro, Eduardo
AU - Tamariz, Jesus
AU - Wanger, Audrey
AU - Mason, Edward O.
N1 - Funding Information:
This work was funded in part by a grant from Consejo Nacional de Ciencia y Tecnología (CONCYTEC, Peru) and by an award from Fondo de Apoyo al Investigador Farmaindustria (FAIF 2000, Peru) and supported by the following Peruvian laboratories: Roche, Hoechst Marion Roussel, Eli Lilly, and Becton Dickinson. The authors thank Dr Thomas Cleary for his helpful suggestions and review of the manuscript, Dr Kathleen Kennedy for her help with the data analysis, and Susan Kirby for her secretarial support.
PY - 2005/5
Y1 - 2005/5
N2 - The purpose of this study was to determine the carriage rate, susceptibility pattern, and serotype distribution of Streptococcus pneumoniae in the nasopharynx of children younger than 2 years old in Lima, Peru. A total of 666 children were evaluated during 3 periods, 1997, 2001, and 2003. The overall pneumococcal carrier rate was 41%. Reduced susceptibility to penicillin was found in 5% (4/75) of isolates in 1997, 20% (15/75) in 2001, and 37% (40/109) in 2003. Reduced susceptibility to ceftriaxone was found in 12% of isolates in 2003. Serogroups 6, 19, 23, 15, and 14 accounted for 68% of all the isolates and for 81% of the penicillin-nonsusceptible strains. Only 65% of the isolated strains had serogroups found in the 7-valent conjugate pneumococcal vaccine. This highlights the importance of regional surveillance studies for effective vaccine strategies and treatment protocols.
AB - The purpose of this study was to determine the carriage rate, susceptibility pattern, and serotype distribution of Streptococcus pneumoniae in the nasopharynx of children younger than 2 years old in Lima, Peru. A total of 666 children were evaluated during 3 periods, 1997, 2001, and 2003. The overall pneumococcal carrier rate was 41%. Reduced susceptibility to penicillin was found in 5% (4/75) of isolates in 1997, 20% (15/75) in 2001, and 37% (40/109) in 2003. Reduced susceptibility to ceftriaxone was found in 12% of isolates in 2003. Serogroups 6, 19, 23, 15, and 14 accounted for 68% of all the isolates and for 81% of the penicillin-nonsusceptible strains. Only 65% of the isolated strains had serogroups found in the 7-valent conjugate pneumococcal vaccine. This highlights the importance of regional surveillance studies for effective vaccine strategies and treatment protocols.
KW - Lima, Peru
KW - Penicillin resistance
KW - Streptococcus pneumoniae
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U2 - 10.1016/j.diagmicrobio.2004.12.014
DO - 10.1016/j.diagmicrobio.2004.12.014
M3 - Article
C2 - 15878444
AN - SCOPUS:18844391061
SN - 0732-8893
VL - 52
SP - 59
EP - 64
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
ER -