Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues

S. J. Incavo; P. J. Ronchetti; J. H. Choi; H. Wu; M. Kinzig; F. Sorgel

doi:10.1128/AAC.38.4.905

Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues

S. J. Incavo, P. J. Ronchetti, J. H. Choi, H. Wu, M. Kinzig, F. Sorgel

Research output: Contribution to journal › Comment/debate › peer-review

41 Scopus citations

Abstract

The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 ± 1.8 in cancellous bone tissue and 8.0 ± 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentrations in bone and plasma for cancellous and cortical tissue were 23 and 18%, respectively, for piperacillin and 26 and 22%, respectively, for tazobactam. The concentrations of tazobactam achieved are sufficient to exert anti-β-lactamase activity and supportive of clinical trials involving bone and joint infections, including those caused by β-lactamase-producing pathogens.

Original language	English (US)
Pages (from-to)	905-907
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	38
Issue number	4
DOIs	https://doi.org/10.1128/AAC.38.4.905
State	Published - 1994

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues",

abstract = "The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 ± 1.8 in cancellous bone tissue and 8.0 ± 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentrations in bone and plasma for cancellous and cortical tissue were 23 and 18\%, respectively, for piperacillin and 26 and 22\%, respectively, for tazobactam. The concentrations of tazobactam achieved are sufficient to exert anti-β-lactamase activity and supportive of clinical trials involving bone and joint infections, including those caused by β-lactamase-producing pathogens.",

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AU - Incavo, S. J.

AU - Ronchetti, P. J.

AU - Choi, J. H.

AU - Wu, H.

AU - Kinzig, M.

AU - Sorgel, F.

PY - 1994

Y1 - 1994

N2 - The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 ± 1.8 in cancellous bone tissue and 8.0 ± 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentrations in bone and plasma for cancellous and cortical tissue were 23 and 18%, respectively, for piperacillin and 26 and 22%, respectively, for tazobactam. The concentrations of tazobactam achieved are sufficient to exert anti-β-lactamase activity and supportive of clinical trials involving bone and joint infections, including those caused by β-lactamase-producing pathogens.

AB - The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 ± 1.8 in cancellous bone tissue and 8.0 ± 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentrations in bone and plasma for cancellous and cortical tissue were 23 and 18%, respectively, for piperacillin and 26 and 22%, respectively, for tazobactam. The concentrations of tazobactam achieved are sufficient to exert anti-β-lactamase activity and supportive of clinical trials involving bone and joint infections, including those caused by β-lactamase-producing pathogens.

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Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues

Abstract

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