Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues

S. J. Incavo, P. J. Ronchetti, J. H. Choi, H. Wu, M. Kinzig, F. Sorgel

Research output: Contribution to journalComment/debate

31 Scopus citations

Abstract

The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 ± 1.8 in cancellous bone tissue and 8.0 ± 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentrations in bone and plasma for cancellous and cortical tissue were 23 and 18%, respectively, for piperacillin and 26 and 22%, respectively, for tazobactam. The concentrations of tazobactam achieved are sufficient to exert anti-β-lactamase activity and supportive of clinical trials involving bone and joint infections, including those caused by β-lactamase-producing pathogens.

Original languageEnglish (US)
Pages (from-to)905-907
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume38
Issue number4
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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